Graft versus tumor effect against neuroblastoma: a case report with long-term survival and a review of the literature

Remission With Donor Lymphocyte Infusion in a Child With Marrow Relapse After Haploidentical Stem Cell Transplantation for Relapsed Stage 4 Neuroblastoma

“…Clinical reports on patients with refractory/relapsed neuroblastoma also demonstrated partial or complete response to HSCT using a matched‐sibling, matched‐unrelated individual and a haploidentical individual as a donor . In particular, reports show that residual neuroblastoma disease after allogeneic HSCT could be cleared up with persistent engraftment but no additional treatment, especially during flare up of GvHD . The outcome of neuroblastoma patients after allogeneic HSCT has been variable and less than satisfactory, prompting the need for further studies in disease biology and patient selection …”

“…[11][12][13] In particular, reports show that residual neuroblastoma disease after allogeneic HSCT could be cleared up with persistent engraftment but no additional treatment, especially during flare up of GvHD. [14][15][16] The outcome of neuroblastoma patients after allogeneic HSCT has been variable and less than satisfactory, prompting the need for further studies in disease biology and patient selection. [13] In our patient, disease recurred soon after autologous HSCT in the marrow and skeleton but he was salvaged by allogeneic HSCT with a haploidentical donor.…”