Graft perforations favor osteoinduction

Sigholm, Göran; Gendler, El; McKellop, Harry A.; Gj, Marshall; Moore, Tyler M.; Sarmiento, Alberto Martínez

doi:10.3109/17453679209154818

Cited by 21 publications

(2 citation statements)

References 21 publications

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“…Demineralized freeze dried human bone (Ul-timatics inc. Springdale, USA, Pacific Coast Tissue Bank) was used as grafting material. The demineralization method as described by Gendler, Sigholm and Moore was used (Gendler 1986;Sigholm et al 1992;Moore 1993). Particle size varied from 250-500 mm.…”

Section: Methodsmentioning

confidence: 99%

Maxillary sinusfloor elevation and grafting with human demineralized freeze dried bone

Bergh

Bruggenkate

Krekeler

et al. 2000

Clinical Oral Implants Res

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In the continuous search for the ideal grafting material in this study the authors used human demineralized freeze dried bone (DFDB) in the maxillary sinusfloor elevation surgery. In total 30 sinusgrafts were performed in 24 patients. Residual lateral maxillary bone height was less than 8 mm but more than 4 mm. The surgical technique used was according to the description of Tatum (1986). In those 30 grafted sinuses a total of 69 ITI full body screw implants were placed 6 months after grafting. Four sinuses exhibited a prolonged healing time. All implants were loaded 4 months after insertion. No implant losses or failures occurred. The rough surface ITI dental implant appeared to be a suitable implant following sinusgrafting with DFDB. According to the results of this study the limited sinusfloor elevation procedure with DFDB appears to be a clinical reliable pre-implant procedure.

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Section: Methodsmentioning

confidence: 99%

Maxillary sinusfloor elevation and grafting with human demineralized freeze dried bone

Bergh

Bruggenkate

Krekeler

et al. 2000

Clinical Oral Implants Res

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“…DBM was prepared by the Pacific Coast Tissue Bank, Los Angeles, California. 4,5 They were obtained from canine tibial cortices measuring about 3 x 2 cm each. The DBM was soaked in a solution of normal saline (500 mL), vancomycin (500 mg), gentamicin (40 mg) and cefazolin (1 g) for at least half an hour prior to use.…”

Section: Methodsmentioning

confidence: 99%

Bone Generation in the Reconstruction of a Critical Size Calvarial Defect in an Experimental Model†

Por

Barceló

Salyer

et al. 2007

Ann Acad Med Singap

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Objective: This study was designed to investigate the optimal combination of known osteogenic biomaterials with shape conforming struts to achieve calvarial vault reconstruction, using a canine model. Methods: Eighteen adolescent beagles were divided equally into 6 groups. A critical size defect of 6 x 2 cm traversed the sagittal suture. The biomaterials used for calvarial reconstruction were demineralised perforated bone matrix (DBM), recombinant human bone morphogenetic protein-2 (rhBMP2) and autogenous platelet-rich plasma (PRP). The struts used were cobalt chrome (metal) or resorbable plate. The groupings were as follows: 1) DBM + metal, 2) DBM + PRP + metal, 3) DBM + PRP + resorbable plate, 4) DBM + rhBMP2 + metal, 5) DBM + rhBMP2 + PRP + metal, and 6) DBM + rhBMP2 + resorbable plate. Animals were euthanised at 3 months post-surgery. There was no mortality or major complications. Analysis was performed macroscopically, histologically, and with computed tomography (CT). Results: There was complete bony regeneration in the rhBMP2 groups only. Non-rhBMP2 groups had minimal bony ingrowth from the defect edges and on the dural surface, a finding confirmed by CT scan and histology. PRP did not enhance bone regeneration. Shape conformation was good with both metal and resorbable plate. Conclusion: rhBMP2 but not PRP accelerated calvarial regeneration in 3 months. The DBM in the rhBMP2 groups were substituted by new trabecular bone. Shape molding was good with both metal and resorbable plate. Key words: Critical size calvarial defect, Cranial vault reconstruction, Metal struts, Resorbable plates, rhBMP2

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Biology of Repair of the Immature Skeleton

Skeletal Injury in the Child

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Graft perforations favor osteoinduction

Cited by 21 publications

References 21 publications

Maxillary sinusfloor elevation and grafting with human demineralized freeze dried bone

Maxillary sinusfloor elevation and grafting with human demineralized freeze dried bone

Bone Generation in the Reconstruction of a Critical Size Calvarial Defect in an Experimental Model†

Biology of Repair of the Immature Skeleton

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