Graft-induced behavioral recovery from subcallosal septohippocampal damage in rats depends on maturity stage of donor tissue

Cassel, J.C.; Kelche, Christian; Peterson, Gary M.; Ballough, G.P.; Goepp, I.; Will, Bruno

doi:10.1016/0306-4522(91)90272-p

Cited by 79 publications

(28 citation statements)

References 74 publications

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“…Thus, using a noninvasive correlational approach based on genetically different strains with widely varying morphology, we could confirm results from lesion studies (Gray and McNaughton, 1983), combined lesion/grafting experiments Bjorklund and Gage, 1988;Cassel et al, 1991;Dunnett, 1991;Dalrymple-Alford, 1994), 192 IgGsaporin-treatment experiments (Berger-Sweeney et a]., 1994; Leanza et al, 1995;Waite et al, 1995), and studies on rats with age-dependent loss of cholinergic neurons (Fischer et al, 1989;Schenk et al, 1990;Armstrong et al, 1993), which support a role of the cholinergic septo-hippocampal system in spatial learning and memory processes.…”

Section: Septa1 Gabaergic Neuronssupporting

confidence: 81%

“…Further support for the involvement of the cholinergic system comes from neurochemical experiments (Galey et al, 1989) and from studies in which lesioned animals were grafted with fetal tissue containing cholinergic neurons (Bjorklund and Stenevi, 1985). Under certain conditions, the original learning capacities of the transplanted animals were sometimes, but not always (Buzsaki et al, 1992), partly or completely re-established Bjorklund and Gage, 1988;Cassel et al, 1991;Dunnett, 199 1;Dalrymple-Alford, 1994). Furthermore, age-dependent loss of cholinergic neurons in the basal forebrain has been shown to be correlated with impair-SCHWEGLER ETAL.…”

mentioning

confidence: 93%

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Genetic variation in the morphology of the septo-hippocampal cholinergic and GABAergic systems in mice: II. Morpho-behavioral correlations

et al. 1996

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Section: Septa1 Gabaergic Neuronssupporting

confidence: 81%

mentioning

confidence: 93%

Genetic variation in the morphology of the septo-hippocampal cholinergic and GABAergic systems in mice: II. Morpho-behavioral correlations

et al. 1996

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“…Although most of these neurons appeared to he LNGFR+, the results also revealed the presence of a noncholinergic projection from the transplant, possibly from the GABAergic projection neurons that have been reported to he present in septa1 grafts (see, e.g., Cassel et al, 1991). 'SiLmificant difference from t h e normal g m u p at P < 0.001 '"Difference [rum the lesioned proup a t P < 0.05.…”

Section: Characteristics Of the Cholinergic Reinnervation Of The Hippmentioning

confidence: 86%

Extensive reinnervation of the hippocampus by embryonic basal forebrain cholinergic neurons grafted into the septum of neonatal rats with selective cholinergic lesions

et al. 1996

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Reconstruction of the septohippocampal pathways by axons extending from embryonic cholinergic neuroblasts grafted into the neuron-depleted septum has been explored in the neonatal rat by using a novel lesioning and grafting protocol. Neonatal ablation of the basal forebrain cholinergic projection neurons, accompanied by extensive bilateral cholinergic denervation of the hippocampus and neocortex, was produced at postnatal day (PD) 4 by 192 immunoglobulin (IgG)-saporin intraventricularly. Four days later, cholinergic neuroblasts (from embryonic day 14 rats) were implanted bilaterally into the neuron-depleted septum by using a microtransplantation approach. The results show that homotopically implanted septal neurons survive and integrate well into the developing septal area, extending axons caudally along the myelinated fimbria-fornix and supracallosal pathways that are able to reach the appropriate targets in the denervated hippocampus and cingulate cortex as early as 4 weeks postgrafting. Moreover, the laminar innervation patterns established by the graft-derived axons closely resembled the normal ones and remained essentially unchanged up to at least 6 months, which was the longest postoperative time studied. The reinnervating fibers restored tissue choline acetyltransferase activity (up to 50% of normal) in the dorsal hippocampus and the parietooccipital cortex. Retrograde labeling with Fluoro-Gold from the host hippocampus combined with immunocytochemistry confirmed that most of the projecting neurons, indeed, were cholinergic. The results suggest that the graft-host interactions that are necessary for target-directed axon growth are present in the septohippocampal system during early postnatal maturation. Thus, the present approach may contribute to overcome the functional limitations inherent in the use of ectopically placed intrahippocampal transplants.

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“…Given that fimbriafornix lesions, hippocampal cell ablations, and cholinergic blockade produce yery similar changes in place learning behavior (Cassel and Kelche, 1991), it is very likely that all of the treatments produce their effects by interrupting one or more systems that include cholinergic projections from the diagonal band-septal area to the hippocampus (Shute and Lewis, 1963;Lynch et al, 1978;Mesulam et al, 1983;Fibiger, 1982).…”

Section: Platform Reversalmentioning

confidence: 98%

Similarities vs. differences in place learning and circadian activity in rats after fimbria‐fornix section or ibotenate removal of hippocampal cells

1995

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Damage to either the fimbria-fornix or to the hippocampus can produce a deficit in spatial behavior and change in locomotor activity but the extent to which the two kinds of damage are comparable is not known. Here we contrasted the effects of cathodal sections of the fimbria-fornix with ibotenic acid lesions of the cells of the hippocampus (Ammon's horn and the dentate gyrus) on place learning in a swimming pool and on circadian activity. Rats in both ablation groups were impaired relative to control rats in learning a single place response but they did acquire the response as measured by swim latencies, errors, and by enhanced searching on probe trials. They were also more active than the control group on the test of activity. Nevertheless, the fimbria-fornix group was initially more impaired on learning and was more active than the hippocampal group. Analysis of the strategies used in learning indicated that the lesion groups were very similar to each other but different from the control group especially in that at asymptotic performance, rats in both lesion groups made rather tight loops as they swam toward the platform. This strategy likely contributed to the greater proportion of time they spent swimming in the correct quadrant on the subsequent probe trial. These findings confirm that rats with fimbria-fornix or hippocampal damage display impairments in place learning and are hyperactive but also show that there are lesion differences. The results are discussed with respect to the relative effectiveness of the lesions and the possibility that fibers in the fimbria-fornix may mediate some functions that are not attributable to the hippocampus.

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Graft-induced behavioral recovery from subcallosal septohippocampal damage in rats depends on maturity stage of donor tissue

Cited by 79 publications

References 74 publications

Genetic variation in the morphology of the septo-hippocampal cholinergic and GABAergic systems in mice: II. Morpho-behavioral correlations

Genetic variation in the morphology of the septo-hippocampal cholinergic and GABAergic systems in mice: II. Morpho-behavioral correlations

Extensive reinnervation of the hippocampus by embryonic basal forebrain cholinergic neurons grafted into the septum of neonatal rats with selective cholinergic lesions

Similarities vs. differences in place learning and circadian activity in rats after fimbria‐fornix section or ibotenate removal of hippocampal cells

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