Graft Immunogenicity Revisited: Relevance of Tissue-Specific Immunity, Brain Death and Donor Pretreatment

Woude, Fokko J. van der

doi:10.1159/000058390

Cited by 14 publications

(6 citation statements)

References 25 publications

(32 reference statements)

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“…Stimulated by inflammatory conditions initiated after brain death, the harvesting procedure and amplified by I/R injury, parenchymal cells can overexpress MHC antigens, produce inflammatory cytokines and adhesion molecules, and finally undergo apoptosis. Under those circumstances, these cells can also express MHC class II antigens [27,48].…”

Section: Relationship Between Innate and Adaptive Graft Recognitionmentioning

confidence: 99%

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Modifying graft immunogenicity and immune response prior to transplantation: potential clinical applications of donor and graft treatment

2006

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Summary Many studies have shown a strong association between initial graft injury and poor long‐term graft outcome. Events initiated by unspecific immune‐activating processes including brain death and ischemia/reperfusion injury occurring prior to transplantation reduce graft functionality and amplify the host immune response. These events may be particularly relevant for less than optimal grafts with reduced resistance to unspecific injuries. Several approaches to ameliorate immune activation of the graft by treating the donor or the graft have been studied. While various substances have been shown to have protective effects in experimental transplantation, only a few drugs have been tested clinically and have demonstrated beneficial effects. We review the results of experimental and clinical studies on donor or graft immunomodulation prior to transplantation and analyze the evidence to support clinical application of these strategies.

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Section: Relationship Between Innate and Adaptive Graft Recognitionmentioning

confidence: 99%

“…After brain death, a series of neural, hormonal, and molecular changes occur, resulting in cellular stress and inflammatory response [26,27]. These events lead to reduced cell defense mechanisms and increased graft immunogenicity inducing a host alloimmune response even in the absence of nonself antigens.…”

Section: Graft Activation and Immunogenicitymentioning

confidence: 99%

Modifying graft immunogenicity and immune response prior to transplantation: potential clinical applications of donor and graft treatment

2006

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“…Therefore, understanding the mechanisms causing tissue injury in BD donors and investigating possible strategies to overcome or prevent these harmful processes in BD are essential. As BD promotes inflammation in end‐organs, affects hormone regulation and haemodynamic stability, it is generally accepted that this condition severely influences organ quality [1–3]. BD seems to be associated with a worse ischaemia/reperfusion injury after transplantation [4], although in large animals, this could not be demonstrated [5,6].…”

Section: Introductionmentioning

confidence: 99%

Donor dopamine treatment in brain dead rats is associated with an improvement in renal function early after transplantation and a reduction in renal inflammation

Hoeger¹,

Reisenbuechler²,

Göttmann³

et al. 2008

Transplant International

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Summary Brain death (BD) is associated with tissue inflammation. As dopamine treatment of BD donor rats reduces renal monocyte infiltration, we tested if this treatment affects renal function and inflammation in recipients. BD was induced in F344 rats and was maintained for 6 h in all experiments. Dopamine was given for 6 (DA6) or 3 h (DA3) from the onset of BD. Ventilated non‐BD (NBD) and BD animals served as controls. Kidneys were transplanted into bilaterally nephrectomized Lewis recipients. Serum creatinine (s‐crea) was measured and leukocyte infiltration was assessed 10 days after transplantation. One day after transplantation, s‐crea was significantly reduced in recipients who received a renal allograft from dopamine treated BD or from NBD rats compared to BD vehicle (P < 0.05). Ten days after transplantation, the number of infiltrating monocytes was significantly lower in grafts obtained from dopamine treated and from NBD rats (P < 0.05). A reduced infiltration in these grafts was confirmed by Banff 97 classification. Cytokine‐induced neutrophil‐chemoattractant 1 and interleukin (IL)‐6 mRNA expression were reduced in DA rats compared to BD controls. No difference for macrophage chemoattractant protein 1 and IL‐10 were found. These findings may explain the salutary effect of donor dopamine treatment in renal transplantation.

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“…During the process of transplantation, the graft is exposed to various events that may in turn lead to functional deterioration. Among them, alloantigen-independent factors such as donor brain death (2), cold storage, and ischemia-reperfusion (I/R) injury (3) can lead to a proinflammatory state and thus increase immunogenicity of the graft (4,5). These factors are associated with the development of delayed graft function and acute rejection episodes, both of which are independent risk factors for decreased long-term graft outcome (6).…”

mentioning

confidence: 99%

Influence of Donor Pretreatment with Dopamine on Allogeneic Kidney Transplantation after Prolonged Cold Storage in Rats

Göttmann

Notheisen²,

Brinkkoetter³

et al. 2005

Transplantation

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Graft Immunogenicity Revisited: Relevance of Tissue-Specific Immunity, Brain Death and Donor Pretreatment

Cited by 14 publications

References 25 publications

Modifying graft immunogenicity and immune response prior to transplantation: potential clinical applications of donor and graft treatment

Modifying graft immunogenicity and immune response prior to transplantation: potential clinical applications of donor and graft treatment

Donor dopamine treatment in brain dead rats is associated with an improvement in renal function early after transplantation and a reduction in renal inflammation

Influence of Donor Pretreatment with Dopamine on Allogeneic Kidney Transplantation after Prolonged Cold Storage in Rats

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