Graft copolymerization of anion and cation onto silica and application in mixed-mode of reversed phase/ hydrophilic interaction/ ion exchange chromatography

Wang, Xiang; Peng, Huanjun; Zhang, Zilong; Wu, Jiajia; Yu, Jiayu; Zeng, Hanlin; Yang, Heng; Zhou, Guangming; Peng, Jingdong

doi:10.1016/j.talanta.2023.125055

Cited by 8 publications

(2 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Among these, prevalent techniques include high-performance liquid chromatography (HPLC) Article Related Abbreviations: HPLC, high-performance liquid chromatography; HSCCC, high-speed counter-current chromatography; PTFE, polytetrafluoroethylene; SBE-β-CD, sulfobutyl ether-β-cyclodextrin. [1][2][3], ionic liquid-assisted ligand exchange chromatography [4][5][6], simulated moving bed chromatography [7][8][9], countercurrent chromatography (CCC) [10,11], and supercritical fluid chromatography [12][13][14], among others. Notably, high-speed CCC (HSCCC) distinguishes itself with a distinctive liquid stationary phase, yielding a significantly higher phase ratio compared to solid-phase supported chromatography [15].…”

Section: Introductionmentioning

confidence: 99%

“…The escalating demand for chiral drugs underscores the significance of stereoselective separation to isolate individual enantiomers using diverse chromatographic methodologies. Among these, prevalent techniques include high‐performance liquid chromatography (HPLC) [1–3], ionic liquid‐assisted ligand exchange chromatography [4–6], simulated moving bed chromatography [7–9], countercurrent chromatography (CCC) [10, 11], and supercritical fluid chromatography [12–14], among others. Notably, high‐speed CCC (HSCCC) distinguishes itself with a distinctive liquid stationary phase, yielding a significantly higher phase ratio compared to solid‐phase supported chromatography [15].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Continuous chiral separation process for high‐speed countercurrent chromatography established and scaled up: A case of Voriconazole enantioseparation

Sun,

Huang,

Pei

et al. 2024

J of Separation Science

View full text Add to dashboard Cite

An efficient method for the continuous separation of Voriconazole enantiomers was developed using sulfobutyl ether‐β‐cyclodextrin (SBE‐β‐CD) as a chiral selector in high‐speed countercurrent chromatography (HSCCC) with different types. The separation was performed using a two‐phase solvent system consisting of n‐hexane/ethyl acetate/100 mmol/L phosphate buffer solution (pH = 3.0, containing 50 mmol/L SBE‐β‐CD) (1.5:0.5:2, v/v/v). A fast and predictable scale‐up process was achieved using an analytical DE HSCCC instrument. The optimized parameters were subsequently applied to a preparative Tauto HSCCC instrument, resulting in consistent separation time and enantiomeric purity, with throughput boosted by a remarkable 11‐fold. Preparative HSCCC successfully separated 506 mg of the racemate, delivering enantiomers exceeding 99% purity as confirmed by high‐performance liquid chromatography analysis. This investigation presents an effective methodology for forecasting the HSCCC scale‐up process and attaining continuous separation of chiral drugs.

show abstract