Graft-copolymer of polyacrylamide-tamarind seed gum: Synthesis, characterization and evaluation of flocculating potential in peroral paracetamol suspension

Nandi, Gouranga; Changder, Abhijit; Ghosh, L. K.

doi:10.1016/j.carbpol.2019.03.088

Cited by 42 publications

(15 citation statements)

References 43 publications

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“…Nandi et al developed tamarind gum based copolymeric network and they evaluated oral toxicity profile of the network. Tamarind biocompatibility was proved in this study as confirmed from our finding 38 …”

Section: Discussionsupporting

confidence: 86%

Biocompatible polymeric blend for pH driven delivery of cytarabine: Effect of feed contents on swelling and release kinetics

et al. 2022

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Purpose of this study was to prepare chitosan/tamarind crosslinked poly (methacrylic acid) hydrogels for pH responsive delivery of cytarabine by using aqueous free radical polymerization technique. Polymers were chemically cross-linked with monomer (methacrylic acid) using methylene bisacrylamide as cross-linking agent and ammonium per sulphate as a reaction initiator in aqueous medium. Developed hydrogels were characterized for morphology, physical existence, drug loading (%), compositional and structural analysis, thermal behavior and stability, drug release analysis (pH 1.2 and pH 7.4), and in vivo release kinetics. pH sensitive behavior was established by observing swelling and release behavior at different pH values (1.2 and 7.4). Biocompatibility of network was evaluated through acute oral toxicity studies in rabbits. Results revealed that cytarabine was efficiently loaded in prepared hydrogels with an entrapment efficiency of 54.67%-108.59%. Highest swelling ratio of 38.67 was noticed at pH 7.4. Maximum pH sensitive behavior was seen at pH 7.4 showing maximum drug release up to 94.51%. All developed formulations followed zero order release as confirmed from regression coefficient (R 2 = 0.9912-0.9991). In-vivo studies confirmed enhanced bioavailability of cytarabine. Histopathological examination and hemocompatibility studies proved that developed hydrogel system was safe, biocompatible, nonhemolytic in nature exhibiting no symptoms of dermal, ocular toxicities, and no changes in biochemical parameters of blood and histology of key organs. So, developed hydrogel system can be employed as an excellent drug delivery device where controlled drug delivery is desired.

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Section: Discussionsupporting

confidence: 86%

Biocompatible polymeric blend for pH driven delivery of cytarabine: Effect of feed contents on swelling and release kinetics

et al. 2022

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“…Radiation technique is a very important aspect of polymer modification; in addition, all grafting techniques require an initiator [37]. Tables 1 and 2 show the effect of various initiator concentrations on grafting.…”

Section: Effect Of Initiator On Graftingmentioning

confidence: 99%

Characterization of Microwave-Controlled Polyacrylamide Graft Copolymer of Tamarind Seed Polysaccharide

et al. 2022

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The main objective of the study was to prepare tamarind seed polysaccharide grafted copolymers of polyacrylamide (TSP-g-Am) using a 32 factorial design. Tamarind seed polysaccharide (TSP) was extracted, and grafted copolymer of TSP was prepared using polyacrylamide as copolymer and ceric ammonium nitrate as initiator. Various batches (F1-F9) of TSP-g-Am were prepared, among which F1 showed highest grafting efficiency; hence, the prepared TSP-g-Am (F1) was evaluated for grafting efficiency, conversion, effect of initiator and further characterized using SEM analysis, contact angle determination, DSC analysis, swelling index, swelling and deswelling, and chemical resistance. The contact angle of TSP was found to be 81 ± 2, and that of TSP-g-Am (F1) was found to be 74 ± 2, which indicates that the wetting ability of the grafted copolymer was less than that of the native polymer. The results of thermal analysis indicated that TSP-g-Am had a more stable molecular structure than TSP. The morphology of the grafted polymer was observed from SEM images, and it was observed that the particles was asymmetrical. Antimicrobial activity was also found in the grafted copolymer. The present study concludes that the TSP-g-Am showed an excellent performance in thermal stability and swelling capacity compared with TSP. The detailed structural characteristics, as well as the excellent thermal stability and swelling capacities, will make it beneficial to use the synthesised copolymer as a precursor for the production of large-scale eco-friendly advanced materials with a wide range of applications, acting as a stabiliser, thickener, binder, release retardant, modifier, suspending agent, viscosity enhancer, emulsifying agent, or carrier for novel drug delivery systems in oral, buccal, colon, and ocular systems, and in nanofabrication and wound dressing, and it is also becoming an important part of food, cosmetics, confectionery, and bakery.

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“…X1 X2X3 (a, b = 1, 2, 3) and X 2 i (i = 1, 2, 3) represent the interaction and quadratic terms, respectively [16,17]. The graft copolymer of karaya with acrylamide was characterized by FTIR, DSC, XRD and SEM and % grafting (%G) and % grafting efficiency (%GE) were calculated by using following equations [18]:…”

Section: Experimental Designmentioning

confidence: 99%

Gum Karaya-G-Poly (Acrylamide): Microwave Assisted Synthesis, Optimisation and Characterisation

Kaur

Gupta

2020

Int J App Pharm

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Objective: The objective of the present research is to formulate acrylamide grafted Karaya gum by using microwave-assisted grafting method and optimisation is performed by using Box behnken design. Methods: The extracted mucilage of gum Karaya was modified into grafted gum Karaya by using a microwave-assisted method. Acrylamide was used as monomer and ceric ammonium nitrate (CAN) is used as redox initiator. The experimental design for optimisation include three independent variables gum concentration (X1), ceric ammonium nitrate (CAN) amount (X2) and irradiation time (X3) while the dependent variables were % yield (Y1), % grafting (Y2) and % grafting efficiency (Y3). The optimised formulation was characterized by fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), x-ray diffraction (XRD) and scanning electron microscopy (SEM) analysis. Results: After optimisation the formulation with acrylamide amount 5 g, ceric ammonium nitrate amount 200 mg and irradiation time of 2 min was selected as optimized formulation. The optimised formulation has percentage grafting of 853.5%, with grafting efficiency of 77.59%. Conclusion: The application of box behnken design for optimisation was performed successfully in microwave assisted grafting of acrylamide on karaya gum.

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Graft-copolymer of polyacrylamide-tamarind seed gum: Synthesis, characterization and evaluation of flocculating potential in peroral paracetamol suspension

Cited by 42 publications

References 43 publications

Biocompatible polymeric blend for pH driven delivery of cytarabine: Effect of feed contents on swelling and release kinetics

Biocompatible polymeric blend for pH driven delivery of cytarabine: Effect of feed contents on swelling and release kinetics

Characterization of Microwave-Controlled Polyacrylamide Graft Copolymer of Tamarind Seed Polysaccharide

Gum Karaya-G-Poly (Acrylamide): Microwave Assisted Synthesis, Optimisation and Characterisation

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