Graduated exercise training and progressive resistance training in adolescents with chronic fatigue syndrome: a randomized controlled pilot study

Gordon, Brett; Knapman, Leona; Lubitz, Lionel

doi:10.1177/0269215510371429

Cited by 60 publications

(78 citation statements)

References 26 publications

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“…However, graded aerobic exercise over several months seems to result in significant improvements of fatigue, depression, and self-reported cognitive symptoms [146] [147]. Similarly, when patients with ME/CFS were enrolled into graded aerobic exercise training programs over four weeks, they reported significant improvements in fatigue and depression compared to control groups, indicating that most patients benefited from physical activity [148]. Generally, ME/CFS patients who complete aerobic training seem to experience significant improvements in outcomes compared to baseline.…”

Section: Fatigue Treatmentsmentioning

confidence: 99%

Peripheral and Central Mechanisms of Fatigue in Inflammatory and Noninflammatory Rheumatic Diseases

Staud

2012

Curr Rheumatol Rep

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Fatigue is a common symptom in a large number of medical and psychological disorders including many rheumatologic illnesses. A frequent question for health care providers is related to whether reported fatigue is “in the mind” or “in the body” i.e. central or peripheral. If fatigue occurs at rest without any exertion this suggests psychological or central origins. If patients relate their fatigue mostly to physical activities including exercise then their symptoms can be considered peripheral. However, most fatiguing syndromes seem to depend on both peripheral and central mechanisms. Sometimes muscle biopsy with histochemistry may be necessary for the appropriate tissue diagnosis whereas serological tests generally provide little reliable information about the origin of muscle fatigue. Muscle function and peripheral fatigue can be quantified by contractile force and action potential measurements whereas validated questionnaires are frequently used for assessment of mental fatigue. Fatigue is a hallmark of many rheumatologic conditions including fibromyalgia, myalgic encephalitis/chronic fatigue syndrome, rheumatoid arthritis, systemic lupus, Sjogren’s syndrome and ankylosing spondylitis. Whereas many studies have focused on disease activity as a correlate to these patients’ fatigue it has become apparent that other factors including negative affect and pain are some of the most powerful predictors for fatigue. Conversely sleep problems, including insomnia seem to be less important for fatigue. There are several effective treatment strategies available for fatigued patients with rheumatologic disorders including pharmacological and non-pharmacological therapies

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Section: Fatigue Treatmentsmentioning

confidence: 99%

Peripheral and Central Mechanisms of Fatigue in Inflammatory and Noninflammatory Rheumatic Diseases

Staud

2012

Curr Rheumatol Rep

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“…There is good evidence that CBT delivered individually (Stulemeijer, de Jong, Fiselier, Hoogveld, & Bleijenberg, 2005), with biofeedback (Al-Haggar, Al-Naggar, & Abdel-Salam, 2006) or via the Internet (Nijhof, Bleijenberg, Uiterwaal, Kimpen, & van de Putte, 2012), is effective at 6 months compared to waiting list or usual medical care. Despite this, at least 20% of young people who access specialist care do not recover at 6 months post-diagnosis (Chalder, Deary, Husain, & Walwyn, 2010; Gordon, Knapman, & Lubitz, 2010; Stulemeijer et al, 2005). …”

Section: Introductionmentioning

confidence: 99%

‘It’s personal to me’: A qualitative study of depression in young people with CFS/ME

Taylor

Loades

Brigden

et al. 2016

Clin Child Psychol Psychiatry

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Background:Paediatric chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) has a prevalence of 0.4–2.4% and is defined as ‘generalised disabling fatigue persisting after routine tests and investigations have failed to identify an obvious underlying cause’. One-third of young people with CFS/ME have probable depression. Little is known about why depression develops, the relationship between depression and CFS/ME, or what treatment might be helpful.Methods:We conducted nine semi-structured interviews with young people with CFS/ME (aged 13–17 years, 8/9 female) and probable depression, covering perceived causes of depression, the relationship between CFS/ME and depression, and treatment strategies.Results:Most thought CFS/ME caused depression. Many discussed a cyclical relationship: low mood made CFS/ME worse. A sense of loss was common. CFS/ME restricted activities participants valued and changed systemic structures, causing depression. There was no single helpful treatment approach. Individualised approaches using combinations of cognitive behavioural therapy (CBT), medication, activity management and other strategies were described.Conclusion:This study suggests that depression may be secondary to CFS/ME in young people because of the impact of CFS/ME on quality of life. Clinicians treating young people with CFS/ME need to consider strategies to prevent development of depression, and research is needed into approaches that are effective in treating CFS/ME with co-morbid depression.

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“…One small pilot study12 compared GET with progressive resistance training and reported a modest reduction in fatigue severity in both arms (GET group −0.42 (SD ± 0.31), resistance training arm −0.12 (SD ± 0.60)). This study is limited by its sample size (n=22) and it was not powered sufficiently to demonstrate an effect.…”

Section: Graded Exercise Therapymentioning

confidence: 99%

Is there effective behavioural treatment for children with chronic fatigue syndrome/myalgic encephalomyelitis?

Smith

Crawley²

2013

Archives of Disease in Childhood

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Graduated exercise training and progressive resistance training in adolescents with chronic fatigue syndrome: a randomized controlled pilot study

Cited by 60 publications

References 26 publications

Peripheral and Central Mechanisms of Fatigue in Inflammatory and Noninflammatory Rheumatic Diseases

Peripheral and Central Mechanisms of Fatigue in Inflammatory and Noninflammatory Rheumatic Diseases

‘It’s personal to me’: A qualitative study of depression in young people with CFS/ME

Is there effective behavioural treatment for children with chronic fatigue syndrome/myalgic encephalomyelitis?

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