Health science libraries have been using information technology since the late 1960s, shaping both the profession and the mission of these libraries. To explore the impact of technology, a series of articles has been commissioned for the HILJ Regular Feature, International Perspectives and Initiatives. This editorial sets the scene for this series of articles, which starts in this issue. These articles, written by health science librarians from around the globe, will explore the impact of technology on the way health science libraries provide information in the digital age. Some articles will look at national trends and others will focus on a particular library. A key theme is how technology is being used to support the mission of health science libraries and whether technology has altered that mission. This editorial provides a brief overview of the technologies libraries have adopted, from the 1970s to the present day. From this, it is clear that information technology has transformed the way health information is collected, catalogued, and disseminated to users. And it is certain that in the coming decade new technologies will be incorporated into health science libraries, which will pose challenges for both users and librarians. However, librarians will continue to find ways to adapt and use these tools to meet the needs of their users.