Grading Solid Pseudopapillary Tumors of the Pancreas: the Fudan Prognostic Index

Yang, Feng; Wu, Wen-Chuan; Wang, Xiaoyi; Zhang, Qiongyan; Bao, Yun; Zhou, Zhongwen; Jin, Chen; Ji, Yuan; Windsor, John A.; Lou, Wenhui; Fu, Deliang

doi:10.1245/s10434-020-08626-z

Cited by 17 publications

(19 citation statements)

References 28 publications

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“…PPI was linked to a higher risk of recurrence in three studies [13,19,21]. High Ki-67 index correlated with SPN relapse in three recently published studies [22,23,25]. However, there was no statistically significant correlation between SPN recurrence and other malignant factors (i.e., perineural invasion, capsular invasion, and lymph node metastasis) in most of the reviewed studies.…”

Section: Author/ Yearmentioning

confidence: 93%

“…Thirteen articles published between 2008 and 2021 were reviewed [13][14][15][16][17][18][19][20][21][22][23][24][25]. All of them were retrospective cohort studies.…”

Section: Literature Review and Analysismentioning

confidence: 99%

“…The vast majority of patients survived the recurrence. The time to recurrence was available in nine articles for 45 patients, and the median time to recurrence differed very much among studies between 1.5 years and 6 years [14][15][16][18][19][20][23][24][25]. The shortest recurrence was reported at 4 months and the longest at 170 months.…”

Section: Literature Review and Analysismentioning

confidence: 99%

“…LVI was found to be significantly associated with increased recurrence in six studies [13,18,21,[23][24][25]. PPI was linked to a higher risk of recurrence in three studies [13,19,21].…”

Section: Author/ Yearmentioning

confidence: 99%

“…The exact biological behavior of SPNs is still unknown, and histological features have not been found to correlate with the prognosis of these tumors. Although factors associated with the relapses of SPNs have been reported in several studies, no conclusive criteria have been established till now for predicting the recurrence of SPNs [13][14][15][16][17][18][19][20][21][22][23][24][25].…”

Section: Introductionmentioning

confidence: 99%

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Prediction of Recurrence Risk in Solid Pseudopapillary Neoplasm of the Pancreas: Single-Institution Experience

Rathi

Anuragi

et al. 2021

Cureus

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Background: Solid pseudopapillary neoplasm (SPN) of the pancreas is a low-grade malignant neoplasm with unpredictable behavior. Factors associated with recurrence were not conclusively identified. The aim of this study is to define the clinicopathological criteria for recurrence risk prediction in SPNs based on the most recent scientific evidence and to present our experience with SPNs.Methods: A retrospective review of patients with SPNs operated on in our institution from June 2012 to June 2018 was completed. Patient characteristics and clinical outcomes were analyzed. A detailed literature review was performed to evaluate the factors associated with the recurrence of SPNs.Results: The cohort consisted of 13 female patients with a median age of 24 years and a mean tumor size of 7.7 cm. Body and tail (53.8%) were the most common location, and distal pancreatectomy with splenectomy was the prevalent surgical procedure. One patient of SPN operated on for local recurrence after 11 years which had high-grade malignant histological features on the previously resected tumor. At a median followup of 42 months (range 36 to 108), all patients were disease free and alive. The proposed criteria for predicting recurrence in SPNs include tumor size >8 cm, synchronous metastasis, malignant SPN (according to 2000 or 2010 World Health Organization [WHO] criteria), lymphovascular invasion, pancreatic parenchymal invasion, and high Ki-67 index (>4%). All these are worse prognostic factors and should be considered as high-risk factors for postoperative relapse. Conclusion:The above-mentioned criteria can better predict SPN recurrence. Patients with high-risk features should undergo an extended follow-up.

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Section: Author/ Yearmentioning

confidence: 93%

“…Thirteen articles published between 2008 and 2021 were reviewed [13][14][15][16][17][18][19][20][21][22][23][24][25]. All of them were retrospective cohort studies.…”

Section: Literature Review and Analysismentioning

confidence: 99%

Section: Literature Review and Analysismentioning

confidence: 99%

“…LVI was found to be significantly associated with increased recurrence in six studies [13,18,21,[23][24][25]. PPI was linked to a higher risk of recurrence in three studies [13,19,21].…”

Section: Author/ Yearmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Prediction of Recurrence Risk in Solid Pseudopapillary Neoplasm of the Pancreas: Single-Institution Experience

Rathi

Anuragi

et al. 2021

Cureus

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Pancreatic Resection for Solid Pseudopapillary Neoplasms

Jiang

2022

The IASGO Textbook of Multi-Disciplinary Management of Hepato-Pancreato-Biliary Diseases

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Solid Pseudopapillary Neoplasms of the Pancreas Across Races Demonstrate Disparities with Comparably Good Prognosis

Lin

Burkhart

et al. 2022

World j. surg.

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Background Solid pseudopapillary neoplasms (SPNs) of the pancreas are rare with low‐grade malignancy and unclarified clinicopathological features. This study aimed to examine their characteristics and re‐evaluate current treatments. Methods Databases from three sources were screened for patients with SPNs. We compared the perioperative variables, clinical data, overall survival (OS), and prognostic factors for recurrence among the three corresponding cohorts. Results We identified 286 patients diagnosed with SPNs between 1988 and 2020. Patients were mostly women (81%; median age: 38 years), and peak incidence was observed in women of 20–29 years of age. SPNs had a peak incidence in Asian men at 50–59 years of age (p = 0.002) and a delayed peak incidence in Asian women at 30–39 years of age (p < 0.001). Treatment strategies differed significantly across the institutions and included variations in the number of harvested lymph nodes and rates of vascular resection. Lymph node positivity was the only predictor of postoperative recurrence (odds ratio, 2.2; 95% confidence interval, 1.38–2.99; p = 0.007). Higher rates of lymphovascular invasion (p = 0.02), perineural invasion (p < 0.001), and R1 margin involvement (p < 0.001), as seen in one institution, did not result in poorer long‐term survival in terms of the overall (p = 0.43), SPN‐specific (p = 0.69), and recurrence‐free survivals (p = 0.067). Conclusions In contrast to previous findings that SPNs are prevalent in young women, a racial predilection for middle‐aged Asian men and a delayed female peak incidence were noted. Parenchyma‐preserving pancreatectomy may be an acceptable treatment. Non‐radical surgery may be appropriate in patients with multiple comorbidities.

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Grading Solid Pseudopapillary Tumors of the Pancreas: the Fudan Prognostic Index

Cited by 17 publications

References 28 publications

Prediction of Recurrence Risk in Solid Pseudopapillary Neoplasm of the Pancreas: Single-Institution Experience

Prediction of Recurrence Risk in Solid Pseudopapillary Neoplasm of the Pancreas: Single-Institution Experience

Pancreatic Resection for Solid Pseudopapillary Neoplasms

Solid Pseudopapillary Neoplasms of the Pancreas Across Races Demonstrate Disparities with Comparably Good Prognosis

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