Grading of soft tissue sarcomas: from histological to molecular assessment

Neuville, Agnès; Chibon, Fréderic; Coindre, Jean‐Michel

doi:10.1097/pat.0000000000000048

Cited by 99 publications

(73 citation statements)

References 35 publications

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“…The final diagnosis was of a well-differentiated grade I LMS. 6 As a result of this diagnosis, further surgery was deemed necessary. Preoperatively, a contrast computed tomography (CT) scan showed thickening of the soft tissue adjacent to the inferior right hemimandibular surface, without bone or neck lymph node involvement.…”

Section: Discussionmentioning

confidence: 99%

Gingival Leiomyosarcoma in a Young Woman: Case report and literature review

Viviano

Miracco

Lorenzini

et al. 2018

Sultan Qaboos Univ Med J

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Leiomyosarcoma (LMS) is a rare mesenchymal malignancy, of which 3-10% of cases occur in the head and neck region. We report a 22-year-old woman who was referred to the University Hospital of Siena, Italy, in 2016 with an ostensibly benign asymptomatic lump on the mandibular gingiva. The lesion grew rapidly, causing otalgia in the right ear. An excisional biopsy was performed and primary LMS was diagnosed histologically. Subsequently, the patient underwent radical re-excision of the perilesional mucosa, a partial bone resection and the extraction of four teeth. No recurrences or metastases were detectable at a 20-month follow-up. This report discusses the differential diagnosis of LMS with regards to other benign and malignant lesions and reviews the recent literature on primary and secondary oral LMS. Due to its innocuous clinical features-including its asymptomatic nature and presentation at a young age-this aggressive malignancy can go undetected; therefore, an early histopathological diagnosis is crucial.

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Section: Discussionmentioning

confidence: 99%

Gingival Leiomyosarcoma in a Young Woman: Case report and literature review

Viviano

Miracco

Lorenzini

et al. 2018

Sultan Qaboos Univ Med J

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“…While MFSs of the visceral organs are uncommon, they have been reported to occur in the heart, the aorta, the thyroid gland, and the brain [2]. Urological MFS tumors of the penis, spermatic cord, kidneys, and prostate are also rare, and less than 30 cases have been reported in the period between 1970 and 2000 [1,5,[7][8][9].…”

Section: Discussionmentioning

confidence: 99%

“…It was previously known as the myxoid variant of malignant fibrous histiocytoma [6], and is regarded as a malignant fibroblastic lesion with variable myxoid stroma. Histologically, MFS can be classified into three grades according to the grading system of the French Federation of Cancer Centers Sarcoma group (FNCLCC) [7]. Intermediate grade (grade 2) and high-grade (grade 3) neoplasms have a local recurrence rate of over 50%, and display high metastatic potential [5].…”

Section: Introductionmentioning

confidence: 99%

Primary renal myxofibrosarcoma in a woman: A case report and literaturereview

Kim¹,

Suh²,

Kim³

et al. 2017

J Cytol Histol

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A 45-year-old previously healthy woman presented to our hospital with a right abdominal mass. Abdominal computed tomography (CT), magnetic resonance imaging, and bone scanning revealed a 15 cm×10 cm×14 cm, well-delineated, retroperitoneal tumor originating from the right kidney. No metastases detected. The patient underwent successful extirpation of the renal tumor. The tumor showed 50% necrosis without perirenal fat infiltration, and it was diagnosed as a high-grade (grade 3) myxofibrosarcoma without nodal positivity, according to the French Federation of Cancer Centers Sarcoma (FNCLCC) grading system. Tumor immunohistochemical staining revealed positive staining for CD34, Ki67, smooth muscle actin (SMA), and cluster of differentiation 68 (CD68), and negative staining for S100 protein, desmin, mast/stem cell growth factor receptor (c-kit), and melanoma marker antibody (HMB45). Three months post-surgery, follow-up CT revealed no new abdominal metastasis, and the patient is currently receiving routine follow-up without any additional systemic therapy. Myxofibrosarcoma of the kidney is an uncommon soft tissue tumor, and radical surgery is the treatment of choice. Long-term follow-up is recommended because of the tumor's aggressive invasiveness and potential for distant metastasis.

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“…30 Furthermore, in the past decade, greater emphasis has been placed on identifying the underlying molecular drivers of sarcomas. 31 Several potential novel, systemic therapies for soft-tissue sarcoma have been identified, including MDM2 targets, cyclin-dependent kinase 4 inhibitors, peroxisome proliferator-activated receptors (critical regulators of normal adipocyte differentiation), and tyrosine kinase receptors. 32 Other targets reported but not yet tested include YEATS4, c-Jun, and JNK.…”

Section: Well-differentiated Liposarcoma (24%)mentioning

confidence: 99%