Grading and Prognostic Significance of Urologic Carcinomas

Helpap, B.

doi:10.1159/000282345

Cited by 24 publications

(7 citation statements)

References 41 publications

(52 reference statements)

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“…The differences between the two groups examining either AgNORs or nucleoli were highly significant. These data are in accordance with the findings from cellular kinetic studies using autoradiographic analyses in combination with the immunohistochemical staining pattern of tissue polypeptide antigen and carcinoembryonic antigen [10,12].…”

Section: Discussionsupporting

confidence: 90%

Nucleolar and argyrophilic nucleolar organizer region counts in urothelial carcinomas with special emphasis on grade II tumors

Helpap

Bulatko

1994

Vichows Archiv A Pathol Anat

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Prognostic assessment of bladder carcinomas of intermediate differentiation is difficult. This study therefore investigated the prognostic values of nucleolar status and silver staining of argyrophilic nucleolar organizer regions (AgNORs) in grade II bladder carcinomas. In biopsies from 34 grade II transitional cell carcinomas of the urinary bladder the number of nuclei with nucleoli, the location of nucleoli within the nucleus and the number of AgNORs were determined in 1000 or 200 nuclei per section respectively. Ten biopsies showing normal urothelium, 18 cases with mild to severe atypia, 27 grade I, 34 grade II and 12 grade III transitional cell carcinomas were also studied. Significantly differing nucleolar and AgNOR values were found comparing normal urothelium/grade I carcinomas with severe urothelial atypia/grade III carcinomas. Grade II carcinomas, however, were inhomogeneous. One subgroup had nucleolar and AgNOR values resembling grade I carcinomas while the second group had values similar to those of grade III carcinomas. This subdivision of grade II carcinomas correlates with results reported for DNA-cytometry. The results suggest a subdivision of patients with grade II transitional cell carcinomas into a low risk and high risk group.

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Section: Discussionsupporting

confidence: 90%

Nucleolar and argyrophilic nucleolar organizer region counts in urothelial carcinomas with special emphasis on grade II tumors

Helpap

Bulatko

1994

Vichows Archiv A Pathol Anat

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“…The clinical staging was between Ta and T4; the staging was defined according to the 'tumour-node-metastases' (TNM, 1997) clinicopathological staging system [7]. The histological grade of the tumor was assessed using modifications of the 1973 WHO criteria [8]. Of the 1,103 TURs, 612 (55.4%) were Ta-T1 transitional cell tumors and the other bladder specimens were of inflammatory bladder tissue or infiltrating bladder tumors (T2-T4).…”

Section: Methodsmentioning

confidence: 99%

Significance of Protein p53 Overexpression in the Clinical Course of High-Risk Superficial Bladder Cancer

Álvarez

Allepuz²,

Blas³

et al. 2003

Urol Int

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Objectives: This is a retrospective study in which the long-term biological behavior of 67 ‘high-risk’ superficial bladder tumors and the prognostic relevance (prediction of disease recurrence and progression) of the determination of the p53 phenotype in these cases were studied. Material and Methods: 67 tumors with a ‘high risk’ of progression were selected from the 1,103 transurethral resections for bladder cancer carried out in 640 patients in this center between 1987 and 1992. These included 39 T1G3, 14 Tis (isolated or associated with Ta-T1, non-G3 tumors), and 14 Ta-T1, non-G3 tumors with submucosal lymphatic affection (L+). The median follow-up of these cases was 69.7 months. An immunohistochemical technique with monoclonal antibodies (DO-7) was used to detect the p53 phenotype in paraffin-fixed material. Results: Tumor recurrence occurred in 31 patients (46.3%) and local or distant progression in 14 (20.9%). Radical cystectomy was carried out in 16 (23.9%) cases. p53 overexpression of ≧20% (‘p53+’) was detected in 40 tumors (59.7%). The rate of recurrence and progression, the disease and progression-free intervals, cancer-specific survival, disease-free survival and progression-free survival were similar in the 3 tumor groups (in all cases, p > 0.05). There were no significant differences in the overexpression of protein p53, using the standard cutoff point of 20% stained nuclei, on comparing the same variables in the whole group of 67 patients (in all cases, p > 0.05). Conclusion: The detection of protein p53 was not found to be of use in the retrospective prediction of disease progression or survival in ‘high-risk’ superficial bladder cancer.

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“…In addition, epidermal growth factor (EGF) receptor and vascular endothelial growth factor (VEGF) receptor expression in the surrounding tissue have been suggested to predict the likelihood of tumor recurrence [15,16,17,18,22,24,32,33,52] (Table 2). These include Ki67 or in its tissue form as MIB-1, cytokeratins, CK20, 34 beta E12, mutations in chromosome 9p21, and mutations of FGF3.…”

Section: Immunohistochemical and Molecular Markers For Stratificationmentioning

confidence: 99%

Molecular pathology of non-invasive urothelial carcinomas (part I)

Helpap

Schmitz‐Dräger

Hamilton³

et al. 2003

Virchows Arch

Self Cite

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An international consultation on the diagnosis of non-invasive urothelial neoplasms was held in Ancona, Italy in May 2001. Besides histology and problems of classification, one group of experts (Committee no. 3) discussed the molecular pathology and cytometry of noninvasive urothelial carcinomas. In the following first part, special immunohistochemical and molecular markers for stratifications in bladder cancer were discussed including different cytokeratins (clone 34bE12, CK 20), cell proliferation markers (Ki67/MIB-1, PCNA, AgNOR, DNA-cytometry), tumor suppressor genes and oncogenes (p53, p21, erb-B2, bcl-2), different receptor expressions of epidermal growth factor and vascular endothelial growth factor and others. These molecular markers were analyzed in diagnosis of urothelial carcinomas, recurrences, progression and response to treatment.

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Grading and Prognostic Significance of Urologic Carcinomas

Cited by 24 publications

References 41 publications

Nucleolar and argyrophilic nucleolar organizer region counts in urothelial carcinomas with special emphasis on grade II tumors

Nucleolar and argyrophilic nucleolar organizer region counts in urothelial carcinomas with special emphasis on grade II tumors

Significance of Protein p53 Overexpression in the Clinical Course of High-Risk Superficial Bladder Cancer

Molecular pathology of non-invasive urothelial carcinomas (part I)

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