Gradient Sensing: Engineering the Yeast Love Affair

Goryachev, Andrew B.; Leda, Marcin

doi:10.1016/j.cub.2016.04.025

Cited by 1 publication

(2 citation statements)

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“…Bacteria continuously move through a concentration gradient and use local sampling in conjunction with temporal averaging to bias their movement towards the gradient source. This appears to be similar to local sampling as described in budding and fission yeast where the polarised assembly 'moves' through the gradient [53]. How could yeasts and metazoans compare the temporally offset measurements?…”

Section: Local Sampling Versus Global Inhibitory Signalling à a Modelsupporting

confidence: 63%

“…This appears to be similar to local sampling as described in budding and fission yeast where the polarised assembly 'moves' through the gradient [53]. How is this possible in a local sampling system in which a single concentration is measured per sampling and how could a single measurement let the cell commit to growth towards a single direction?…”

Section: Local Sampling Versus Global Inhibitory Signalling à a Modelmentioning

confidence: 79%

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Local sampling paints a global picture: Local concentration measurements sense direction in complex chemical gradients

Hegemann

Peter

2017

BioEssays

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Detecting and interpreting extracellular spatial signals is essential for cellular orientation within complex environments, such as during directed cell migration or growth in multicellular development. Although the molecular understanding of how cells read spatial signals like chemical gradients is still lacking, recent work has revealed that stochastic processes at different temporal and spatial scales are at the core of this gradient sensing process in a wide range of eukaryotes. Fast biochemical reactions like those underlying GTPase activity dynamics form a functional module together with slower cell morphological changes driven by membrane remodelling. This biochemical-morphological module explores the environment by stochastic local concentration sampling to determine the source of the gradient signal, enabling efficient signal detection and interpretation before polarised growth or migration towards the gradient source is initiated. Here we review recent data describing local sampling and propose a model of local fast and slow feedback counteracted by gradient-dependent substrate limitation to be at the core of gradient sensing by local sampling.

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Section: Local Sampling Versus Global Inhibitory Signalling à a Modelsupporting

confidence: 63%

Section: Local Sampling Versus Global Inhibitory Signalling à a Modelmentioning

confidence: 79%

Local sampling paints a global picture: Local concentration measurements sense direction in complex chemical gradients

Hegemann

Peter

2017

BioEssays

View full text Add to dashboard Cite

show abstract

Gradient Sensing: Engineering the Yeast Love Affair

Abstract: A new study in fission yeasts promotes the notion that transient polarity patches that wander the cell surface at the onset of mating are discrete agents of gradient sensing. This concept unexpectedly bridges the modes of gradient sensing in eukaryotes and prokaryotes.

Cited by 1 publication

References 20 publications

Local sampling paints a global picture: Local concentration measurements sense direction in complex chemical gradients

Local sampling paints a global picture: Local concentration measurements sense direction in complex chemical gradients

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