Gradient scaffolds for osteochondral tissue engineering and regeneration

Zhang, Bin; Huang, Jie; Narayan, Roger J.

doi:10.1039/d0tb00688b

Cited by 106 publications

(125 citation statements)

References 134 publications

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“…Given the morphological characteristics in cellular behavior [69][70][71][72][73][74], scaffolds with controlled morphology and chemic should improve osteochondral regeneration, in combination with materials whose properties are known as instructive beings. Accordingly, as demonstrated in Table 1, several types of biocompatible materials have been used to build scaffolds for the osteochondral tissue, including natural polymers, synthetic polymers, metallic polymers, and inorganic polymers [75]. The natural polymers frequently employed are collagen, gelatin, chitosan, alginate, and silk [57].…”

Section: Biomaterialsmentioning

confidence: 99%

“…Collagen is clearly a natural choice for regenerative medicine or osteochondral TE, since it is the most common protein found in ECM, making up about 90% of the dry weight of articular cartilage [79,80]. The synthetic polymers commonly used for the production of scaffolds for osteochondral regeneration are poly (ε-caprolactone) (PCL), poly(lactic acid-coglycolic) (PLGA), poly (ethylene oxide) (PEO), polyglycolic acid, poly (lactic acid) (PLA), PEG, polyactic acid, polydioxanone, and poly(propylene fumarate) [75,91]. These polymers are hydrophobic and can manipulate the properties of the material to achieve the appropriate mechanical behavior.…”

Section: Biomaterialsmentioning

confidence: 99%

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Challenges and Innovations in Osteochondral Regeneration: Insights from Biology and Inputs from Bioengineering toward the Optimization of Tissue Engineering Strategies

Morouço

Fernandes

Lattanzi

2021

JFB

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Due to the extremely high incidence of lesions and diseases in aging population, it is critical to put all efforts into developing a successful implant for osteochondral tissue regeneration. Many of the patients undergoing surgery present osteochondral fissure extending until the subchondral bone (corresponding to a IV grade according to the conventional radiographic classification by Berndt and Harty). Therefore, strategies for functional tissue regeneration should also aim at healing the subchondral bone and joint interface, besides hyaline cartilage. With the ambition of contributing to solving this problem, several research groups have been working intensively on the development of tailored implants that could promote that complex osteochondral regeneration. These implants may be manufactured through a wide variety of processes and use a wide variety of (bio)materials. This review aimed to examine the state of the art regarding the challenges, advantages, and drawbacks of the current strategies for osteochondral regeneration. One of the most promising approaches relies on the principles of additive manufacturing, where technologies are used that allow for the production of complex 3D structures with a high level of control, intended and predefined geometry, size, and interconnected pores, in a reproducible way. However, not all materials are suitable for these processes, and their features should be examined, targeting a successful regeneration.

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Section: Biomaterialsmentioning

confidence: 99%

Section: Biomaterialsmentioning

confidence: 99%

Challenges and Innovations in Osteochondral Regeneration: Insights from Biology and Inputs from Bioengineering toward the Optimization of Tissue Engineering Strategies

Morouço

Fernandes

Lattanzi

2021

JFB

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“…Hence, single homogeneous scaffolds have difficulties meeting the full complexity of the chondro-osseous junction tissue, and so hierarchical scaffolds with gradient physical and chemical properties are essential to produce smooth transitions between skeletal tissues with significant differences. The most successful OC tissue-engineered designs are based on bi-/multi-layered matrices that exhibit a discrete gradient of biochemical, structural and mechanical features, or matrices with a continuous gradient of properties, where there is no distinct interface between each layer [ 86 , 91 ]. This is schematically illustrated in Figure 2 .…”

Section: Osteochondral Tissue Engineeringmentioning

confidence: 99%

“…This is schematically illustrated in Figure 2 . While discrete gradient scaffolds are fabricated by integrating individual phases into a single construct by suturing, glueing, or press-fitting, continuous gradient scaffolds do not exhibit individual layers and are instead fabricated as a single matrix with gradient properties [ 91 , 92 , 93 ]. This is especially relevant since discrete gradient scaffolds are known to show abrupt and substantial changes in terms of the structural and mechanical properties of the different phases, which is often associated with layer delamination and tissue separation upon loading [ 81 , 91 ].…”

Section: Osteochondral Tissue Engineeringmentioning

confidence: 99%

Osteochondral Tissue Engineering: The Potential of Electrospinning and Additive Manufacturing

Gonçalves¹,

Moreira²,

Weber

et al. 2021

Pharmaceutics

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The socioeconomic impact of osteochondral (OC) damage has been increasing steadily over time in the global population, and the promise of tissue engineering in generating biomimetic tissues replicating the physiological OC environment and architecture has been falling short of its projected potential. The most recent advances in OC tissue engineering are summarised in this work, with a focus on electrospun and 3D printed biomaterials combined with stem cells and biochemical stimuli, to identify what is causing this pitfall between the bench and the patients’ bedside. Even though significant progress has been achieved in electrospinning, 3D-(bio)printing, and induced pluripotent stem cell (iPSC) technologies, it is still challenging to artificially emulate the OC interface and achieve complete regeneration of bone and cartilage tissues. Their intricate architecture and the need for tight spatiotemporal control of cellular and biochemical cues hinder the attainment of long-term functional integration of tissue-engineered constructs. Moreover, this complexity and the high variability in experimental conditions used in different studies undermine the scalability and reproducibility of prospective regenerative medicine solutions. It is clear that further development of standardised, integrative, and economically viable methods regarding scaffold production, cell selection, and additional biochemical and biomechanical stimulation is likely to be the key to accelerate the clinical translation and fill the gap in OC treatment.

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“…Accidents resulting in bone trauma, degenerative diseases at the bone level and failed implantation of bone substitutes are generating the highest demand in terms of artificial materials with suitable properties for hard tissue engineering [1]. As a consequence, modern medicine must respond to the challenges imposed by the need to increase the quality of life for the patients involved in such scenarios [2,3].…”

Section: Introductionmentioning

confidence: 99%

Development of New Mg- or Sr-Containing Bioactive Interfaces to Stimulate Osseointegration of Metallic Implants

et al. 2020

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The purpose of this study resides in the design and deposition of several types of bioactive interfaces with complex composition, targeting a superior osseointegration of bone implants. The experimental approach is framed by two oxide systems, SiO2‒CaO‒P2O5‒ZnO‒MgO and SiO2‒CaO‒P2O5‒ZnO‒SrO, while the percentage values were established as optimised solutions for ensuring wear resistance, bioactivity and beneficial effects on cell metabolism and reproduction. Moreover, two methods dedicated to fils growth (pulsed laser deposition and spin coating) were explored as potential variants for coating the bioinert materials and providing a transitional anchoring layer between the artificial substitute and host tissue. The obtained layers were evaluated as vitroceramic in nature, nanostructured in morphology and bioactive in relation to the physiological environment. The response of human fetal osteoblasts placed in contact with the new engineered surfaces was characterized by a significant proliferation from 1 to 4 days, which validates their suitability for hard tissue applications.

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Gradient scaffolds for osteochondral tissue engineering and regeneration

Abstract: The repair of osteochondral (OC) defects requires a tissue engineering approach to fabricate biological tissue that mimics gradient physiological properties such as the transition zone between cartilage and bone. The...

Cited by 106 publications

References 134 publications

Challenges and Innovations in Osteochondral Regeneration: Insights from Biology and Inputs from Bioengineering toward the Optimization of Tissue Engineering Strategies

Challenges and Innovations in Osteochondral Regeneration: Insights from Biology and Inputs from Bioengineering toward the Optimization of Tissue Engineering Strategies

Osteochondral Tissue Engineering: The Potential of Electrospinning and Additive Manufacturing

Development of New Mg- or Sr-Containing Bioactive Interfaces to Stimulate Osseointegration of Metallic Implants

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