Gradient Relationship between Increased Mean Corpuscular Volume and Mortality Associated with Cerebral Ischemic Stroke and Ischemic Heart Disease: A Longitudinal Study on 66,294 Taiwanese

Abstract

The gradient relationship between mean corpuscular volume (MCV) and mortality due to ischemic vascular disease has not been researched using a large-scale population-based study. This study evaluated the association between MCV and death attributable to cerebrovascular disease (CVD) and cardiovascular disease (CAD) in a large population- and community-based Taiwanese cohort. A longitudinal study with a 9-year follow-up was conducted to evaluate individuals aged 20 years or older who had participated in the Keelung (the northernmost city in Taiwan) community-based integrated screening (abbreviated as KCIS) program since September 1999. The mortality rates associated with CVD and CAD were classified across a range of different MCV levels. Increased MCV levels were associated with an increased risk of CVD/CAD-related death (adjusted hazard ratio [aHR] = 1.42, trend test P = 0.0119). Marginally statistically significant associations were noted for specific deaths from ischemic heart disease (aHR = 1.44, trend test P = 0.0992) and cerebral ischemic stroke (aHR = 1.66, trend test P = 0.0667), respectively, but no significant gradient relationship was noted for death from cerebral hemorrhage stroke (aHR = 1.23, trend test, P = 0.6278). A gradient relationship between baseline MCV level and CVD/CAD-related death was noted, but whether such gradient relationships existed for two specific deaths and how these relationships may be confounded by extraneous factors that were not considered here should be investigated in the future.

Multilevel approach to male fertility by machine learning highlights a hidden link between haematological and spermatogenetic cells

“…Increasing such variables of the red component of blood cells decreases the sperm quantity and quality, although a clear cause‐effect relationship could not be established. This is in line with previous studies detecting an impairment in human health status when erythrocyte distribution 31‐35 and the average globular volume increase, 36‐38 suggesting that sperm parameters are potential health markers 7 …”

“…Two parameters of impaired human health, erythrocyte distribution 31‐35 and average globular volume, 36‐38 were inversely related to total sperm number (adjusted R‐squared: 0.002; coefficient: −4.109 and −0.582, P < .010 and P < .050, respectively) and concentration (adjusted R ‐squared: 0.004; coefficient: −17.022 and −2.229, P < .001 and P < .001, respectively). Moreover, these two blood parameters were inversely related to total sperm motility (adjusted R ‐squared: 0.008; coefficient: −2.658 and −0.237, respectively; P < .001), and directly related to immobility sperm rate (adjusted R ‐squared: 0.008; coefficient: 2.653 and 0.237, P < .010 and P < .050, respectively).…”

Selected Hematological Biomarkers to Predict Acute Mortality in Emergency Department Patients. Recent Polish Hospital Statistics

“…Based on the >100 K incident HD patients and those with higher (>98 fL) MCV levels, a higher all-cause cardiovascular and infectious mortality risk was also currently confirmed by [12]. A gradient relationship between increased MCV and deaths associated with cerebral ischemic stroke (CIS) and ischemic heart disease (IHD) was reported in Taiwanese investigators using a large-scale (66,294) population-based study [13]. In addition, [14,15] reported a positive relation of MCV with clinical response in patients with advanced solid malignancies and gastric cancer after chemotherapy with capecitabine.…”

Red Blood Cells Mean Corpuscular Volume (MCV) and Red Blood Distribution Width (RDW) Parameters as Potential Indicators of Regenerative Potential in Older Patients and Predictors of Acute Mortality – Preliminary Report

“…Based on the >100,000 incident haemodialysis (HD) patients and those with higher (>98 fL) MCV levels, a higher all-cause, cardiovascular, and infectious mortality risk was also confirmed by Dratch et al [6]. A gradient relationship between increased MCV and deaths associated with cerebral ischemic stroke (CIS) and ischemic heart disease (IHD) was reported by Taiwanese investigators using a large-scale (66,294) population-based study [7].…”