Gradient regulation of osteo-immune microenvironment by chitooligosaccharide-containing ion-doped mesoporous silica nanoparticles to accelerate osteogenesis

3D Printing of Diatomite Incorporated Composite Scaffolds for Skin Repair of Deep Burn Wounds

“…Although GelMA is well known for its good degradability and biocompatibility, there are still endotoxins inside the material that could initiate inflammatory response[ 52 ]. Fortunately, the microenvironment of enriched Si ions established by silica particles might inhibit the expression of pro-inflammatory-related genes including TNF-α, IL-6, IL-1β, and IL-12b in macrophages[ 53 ]. Therefore, the inflammation of burn wound was prevented in 5DE-Gel group probably due to the inflammation reduced effect of silica.…”

In vitrobiological evaluation of epigallocatechin gallate (EGCG) release from three-dimensional printed (3DP) calcium phosphate bone scaffolds

“…48 EGCG also modulates BGLAP, the most abundant protein in bone and an osteogenic marker at the last stage of osteoblast differentiation, resulting in bone matrix synthesis and mineralization. 49 The Runx2 and BGLAP genes are stimulated by EGCG via the Wnt/β-catenin signaling pathway. 50 The Wnt/β-catenin pathway is activated by binding between Wnt family member 3a (Wnt3a) and membrane receptor complexes such as the frizzled and low density lipoprotein receptor-related proteins 5/6 (Lrp5/6) receptors.…”

Surface modification of titanium substrate via combining photothermal therapy and quorum-sensing-inhibition strategy for improving osseointegration and treating biofilm-associated bacterial infection

“…Thus, bacterial biofilm could be removed under the combined action of QS inhibitor and PTT stimulation to achieve low-temperature PTT. In addition, Ca 2+ and PO 4 3− were released from the rapid degradation of calcium phosphate coating of MPDA-LUT@CaP NPs triggered by acid condition of biofilm infection, which could promote the growth of bone-related cell and the healing process of bone tissue [ [33] , [34] , [35] , [36] , [37] ]. All in all, a pH and NIR dual-responsive nanosystem combining PTT and controlled release of QS inhibitor was constructed on the surface of Ti implant for improving osseointegration and treating biofilm-associated infection.…”