Gradient of microstructural damage along the dentato‐thalamo‐cortical tract in Friedreich ataxia
Sirio Cocozza,
Sara Bosticardo,
Matteo Battocchio
et al.
Abstract:ObjectiveThe dentato‐thalamo‐cortical tract (DTT) is the main cerebellar efferent pathway. Degeneration of the DTT is a core feature of Friedreich ataxia (FRDA). However, it remains unclear whether DTT disruption is spatially specific, with some segments being more impacted than others. This study aimed to investigate microstructural integrity along the DTT in FRDA using a profilometry diffusion MRI (dMRI) approach.MethodsMRI data from 45 individuals with FRDA (mean age: 33.2 ± 13.2, Male/Female: 26/19) and 37… Show more
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