1982
DOI: 10.1002/app.1982.070271034
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Gradient‐IPN‐modified hydrogel beads: Their synthesis by diffusion–polycondensation and function as controlled drug delivery agents

Abstract: SynopsisInterpenetrating polymer network (IPN) membranes and gradient-IPN polymers were synthesized by immersing crosslinked, 2-hydroxyethylmethacrylate copolymer beads which were swollen in polyol in solutions of diisocyanates. Diffusion of reactants and polycondensation take place simultaneously, and the polymer beads are modified by a polyurethane-IPN layer whose thickness and compositional gradient are a function of reaction rate and diffusion rate. When the reaction is fast relative to diffusion, the reac… Show more

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Cited by 41 publications
(15 citation statements)
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“…Gradient structures on hydrogels have attracted much attention. The simple preparation of an interpenetrating polymer network and the concentration of the crosslinker have been investigated for hydrogels with a gradient density of networks. The surface condition of the hydrogel preparation also has a great influence on the physical characteristics .…”
Section: Introductionmentioning
confidence: 99%
“…Gradient structures on hydrogels have attracted much attention. The simple preparation of an interpenetrating polymer network and the concentration of the crosslinker have been investigated for hydrogels with a gradient density of networks. The surface condition of the hydrogel preparation also has a great influence on the physical characteristics .…”
Section: Introductionmentioning
confidence: 99%
“…16 The gradient composition concept has been also applied in small beads prepared by suspension polymerization, to release, in a controlled way, a pharmaceutical drug over a prolonged time, due to the drugdistribution gradient. 17 Looking at particle level, in seeded emulsion polymerizations (SEPs), seed latices have been used to prepare two-component materials in two-stage processes, pursuing properties combination. In such processes, as a consequence of the incompatibility between polymer components, two-phase particles are usually obtained.…”
Section: Introductionmentioning
confidence: 99%
“…The main advantage of such gradient polymers is the possibility, because of their spatial gradient, of making polymer systems with customized properties for different applications. [2][3][4][5][6][7][8][9][10][11] Recently, a new method to create gradient materials has been developed. [12,13] Compared to what is usually encountered in the literature, [14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29] the originality of this method relies on the fact that it does not make use of a mixture containing at least one polymer, but it involves a photopolymerization reaction of a homogeneous system, that is to say a system of monomers and oligomers.…”
Section: Introductionmentioning
confidence: 99%