Gracile projection to the cat medial accessory olive: Ultrastructural termination patterns and convergence with spino‐olivary projection

Molinari, Helen H.; Starr, Kathy A.; Sluyters, Romuald N.

doi:10.1002/cne.903090306

Cited by 9 publications

(2 citation statements)

References 44 publications

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“…Terminal arborizations from the gracile and cuneate nuclei tend to overlap with projections from the lumbosacral and cervical spinal cord, respectively (Boesten and Voogd, 1975;Berkley and Hand, 1978). Using electrophysiological techniques (mapping of responsive fields) (Gellman et al, 1983), but also with the aid of detailed anterograde tracer techniques (Molinari et al, 1991;Matsushita et al, 1992), it has been demonstrated that a detailed somatotopical map can be found within the rostral half of the cat IOD. An additional, but more crude somatotopical representation appears to be present within the caudal half of the cat IOD.…”

Section: Afferents To the Dorsal Accessory Olivementioning

confidence: 98%

Cerebellum and Cerebellar Connections

Ruigrok

Sillitoe

Voogd

2015

The Rat Nervous System

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Section: Afferents To the Dorsal Accessory Olivementioning

confidence: 98%

Cerebellum and Cerebellar Connections

Ruigrok

Sillitoe

Voogd

2015

The Rat Nervous System

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“…Adjacent to the medullary somatosensory nuclei lie other structures that project to the inferior olive, including the solitary complex (Loewy and Burton, 19781, perihypoglossal nuclei (e.g., de Zeeuw et al, 1993) and subnucleus reticularis dorsalis (SRD; Bernard et al, 1990). The projection from the solitary complex arises from the parasolitary nucleus (see Molinari et al, 1991). The parasolitary nucleus can readily be identified in Nissl stained sections (Walberg et al, 1962;Paxinos and Watson, 1986).…”

Section: Evaluation Of Labeling Patternsmentioning

confidence: 99%

Gracile, cuneate, and spinal trigeminal projections to inferior olive in rat and monkey

1996

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In the cat, somatosensory nuclei send substantial projections to the inferior olive, where they terminate in a somatotopic fashion. Although the organization of the cat inferior olive has been used to interpret data from other species, published data suggest this organization may not occur universally. The present study investigated whether the inferior olive in albino rats and cynomolgus monkeys receives the same brainstem somatosensory inputs, whether these inputs are organized somatotopically and, if so, how the organization compares with that in the cat. Projections from the gracile, cuneate and spinal trigeminal nuclei were labeled with wheat germ agglutinin conjugated to horseradish peroxidase or with biotinylated dextran. The results were compared with data from cats (Berkley and Hand [1978] J. Comp. Neurol. 180:253-264). In the rat and monkey, the gracile, cuneate and spinal trigeminal nuclei all project to the contralateral inferior olive, where each nucleus has a distinct preferred terminal field. As in the cat, projections to the medial accessory olive and caudal dorsal accessory olive did not terminate in a precisely organized fashion. Projections to the rostral dorsal accessory olive, however, formed a clear somatotopic map. These somatotopic maps differed from those in the cat in that input from the trigeminal nucleus was confined rostrally, so that the caudal end only received input from the gracile and cuneate nuclei. These data indicate that similar organizational principles characterize the somatosensory projections to the inferior olives of the three species. Nevertheless, distinct species differences occur with regard to the details of this organization.

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Cholinergic projection to the dorsal cap of the inferior olive of the rat, rabbit, and monkey

Barmack

Fagerson

Errico

1993

J of Comparative Neurology

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The inferior olive is divided into several subnuclei that receive specific sensory information. The caudal dorsal cap of the medial accessory subdivision of the inferior olive receives horizontal optokinetic information from the nucleus of the optic tract. The immediately subjacent beta-nucleus receives vertical vestibular information mediated by a GABAergic pathway originating from the ipsilateral descending and medial vestibular nuclei. None of the transmitters to the dorsal cap have been identified. Using choline acetyltransferase (ChAT) immunohistochemistry, we have identified a cholinergic pathway that terminates exclusively in the dorsal cap of rats and monkeys. No other division of the inferior olive received a significant cholinergic innervation. In the rabbit, immunostaining for ChAT reveals a weaker and more diffuse cholinergic innervation of both the dorsal cap and the subjacent beta-nucleus. In rats and rabbits we injected iontophoretically the orthograde tracer Phaseolus vulgaris leucoagglutinin (PHA-L) into the medial and descending vestibular nuclei (MVN, DVN) as well as the nucleus prepositus hypoglossi (NPH) in order to trace the possible origin of the cholinergic projection. PHA-L injections into the NPH and medial aspect of the MVN labeled terminals within the contralateral dorsal cap. PHA-L injections in the central and lateral aspects of the MVN as well as the DVN labeled the ipsilateral beta-nucleus. Pressure injections of wheat germ agglutinin-horseradish peroxidase (WGA-HRP) in the caudal dorsal cap of the rabbit inferior olive demonstrated a predominantly contralateral projection to the dorsal cap from the lateral aspect of the NPH. However, pressure injections of HRP into the caudal dorsal cap combined with ChAT immunohistochemistry in the rabbit demonstrated that most of the neurons of the NPH that projected to the dorsal cap were not cholinergic, and that most of the ChAT-positive neurons within the NPH occupied a more ventral location than the neurons within the NPH that were retrogradely labeled from the HRP injection into the contralateral dorsal cap. In the rat, we made lesions in the MVN, DVN and NPH by injection of ibotenic acid (0.3-0.5 microliter), in an attempt to deplete the dorsal cap of the inferior olive of its cholinergic input. Lesions confined to the NPH and medial aspect of the MVN of the rat caused a loss of ChAT staining in the contralateral dorsal cap. Lesions placed more laterally within the MVN or DVN failed to deplete ChAT-positive terminals in the contralateral or ipsilateral dorsal caps. The dorsal cap of the rat and monkey receives a discrete cholinergic projection.(ABSTRACT TRUNCATED AT 400 WORDS)

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Gracile projection to the cat medial accessory olive: Ultrastructural termination patterns and convergence with spino‐olivary projection

Cited by 9 publications

References 44 publications

Cerebellum and Cerebellar Connections

Cerebellum and Cerebellar Connections

Gracile, cuneate, and spinal trigeminal projections to inferior olive in rat and monkey

Cholinergic projection to the dorsal cap of the inferior olive of the rat, rabbit, and monkey

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