Gracilaria chorda subcritical water ameliorates hepatic lipid accumulation and regulates glucose homeostasis in a hepatic steatosis cell model and obese C57BL/6J mice

Thakuri, Laxmi Sen; Park, Chul Min; Kim, Hyeon-A; Kim, Hyung Jung; Park, Jin Woo; Park, Jong Cheol; Rhyu, Dong Young

doi:10.1016/j.jep.2023.117395

Cited by 2 publications

(2 citation statements)

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“…In this line, a study conducted in mice fed with a high fat diet observed that the administration of a sulphated polysaccharide from Gracilaria lemaneiformis was effective in reducing hepatic lipid deposition [ 14 , 15 ]. In another study, the administration of Gracilaria chorda subcritical water extract in obese C57BL/6J mice ameliorated hepatic lipid accumulation [ 13 ]. The discrepancies between the present study and those reported in the literature may arise from the higher concentration of the mentioned bioactive compounds in the fractions and extracts compared with the whole alga.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, studies have described the potential of Gracilaria sp. to modulate glucose, cholesterol and lipid metabolism [ 13 , 14 , 15 , 16 ]. In fact, in a preceding study conducted by our group, it was observed that an extract derived from Gracilaria vermiculophylla , particularly rich in proteins and peptides, demonstrated the ability to reduce triglyceride accumulation in cultured hepatocytes by increasing fatty acid oxidation [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

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Effect of Gracilaria vermiculophylla Macroalga on Non-Alcoholic Fatty Liver Disease in Obese Rats

González-Arceo,

Aguirre,

Macarulla

et al. 2024

Antioxidants

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Marine algae are valuable sources of bioactive compounds that have the potential to be used in the management of various pathologies. Despite the increasing prevalence of NAFLD, the absence of an approved effective pharmacological treatment with demonstrable effectiveness persists. In this context, the aim of the present study is to assess the effect of Gracilaria vermiculophylla red seaweed dietary supplementation on hepatic lipid accumulation, as well as on oxidative stress, inflammation and fibrosis- related markers on obese fa/fa Zucker rats fed with a standard diet, supplemented or not with 2.5% or 5% dehydrated Gracilaria vermiculophylla. After a six-week supplementation with the macroalga, no significant reduction in hepatic total lipid content or hepatic triglyceride content was observed. However, both doses were able to diminish hepatic NEFA concentration by reducing de novo lipogenesis and increasing mitochondrial biogenesis. Moreover, supplementation with the dose of 2.5% improved some oxidative stress and inflammation-related markers. Supplementation with the dose of 5% did not exert these clear beneficial effects. Thus, this study demonstrates that while Gracilaria vermiculophylla may not mitigate hepatic steatosis, it could exert protective effects on the liver by reducing NEFA content and enhancing oxidative stress and inflammation parameters.

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Section: Discussionmentioning

confidence: 99%