Grab Control! Choosing the Right Comparison Group in an Observational Study

Dettori, Joseph R; Norvell, Daniel C

doi:10.1177/2192568219847206

Cited by 4 publications

(6 citation statements)

References 8 publications

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“…On the other hand, when patients with COVID-like symptoms are used as controls, it is possible to determine which laboratory parameters might be specific for SARS-CoV-2 infection, regardless of the symptoms. 22 …”

Section: Discussionmentioning

confidence: 99%

“…Firstly, there were no COVID-specific parameters among the baseline hematological and biochemical analyses; and secondly, there are a lot of common viral infections among children, which may present with similar laboratory findings. 22 , 23 Therefore, healthy children formed a more convenient control group in our study, given that they showed us various alterations in laboratory parameters such as leukocytosis, lymphopenia, thrombocytosis, elevated SII and NLR, hyponatremia, hypochloremia and elevated levels of AST, ALT, LDH and CRP.…”

Section: Discussionmentioning

confidence: 99%

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Baseline laboratory parameters for preliminary diagnosis of COVID-19 among children: a cross-sectional study

et al. 2022

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BACKGROUND: Clinical judgment of initial baseline laboratory tests plays an important role in triage and preliminary diagnosis among coronavirus disease 2019 (COVID-19) patients. OBJECTIVES: To determine the differences in laboratory parameters between COVID-19 and COVID-like patients, and between COVID-19 and healthy children. Additionally, to ascertain whether healthy children or patients with COVID-like symptoms would form a better control group. DESIGN AND SETTING: Cross-sectional study at the Institute for Child and Youth Health Care of Vojvodina, Novi Sad, Serbia. METHODS: A retrospective study was conducted on 42 pediatric patients of both sexes with COVID-19. Hematological parameters (white blood cell count, absolute lymphocyte count and platelet count) and biochemical parameters (natremia, kalemia, chloremia, aspartate aminotransferase [AST], alanine aminotransferase [ALT], lactate dehydrogenase [LDH] and C-reactive protein [CRP]) were collected. The first control group was formed by 80 healthy children and the second control group was formed by 55 pediatric patients with COVID-like symptoms. RESULTS: Leukocytosis, lymphopenia, thrombocytosis, elevated systemic inflammatory index and neutrophil-lymphocyte ratio, hyponatremia, hypochloremia and elevated levels of AST, ALT, LDH and CRP were present in COVID patients, in comparison with healthy controls, while in comparison with COVID-like controls only lymphopenia was determined. CONCLUSIONS: The presence of leukocytosis, lymphopenia, thrombocytosis, elevated systemic inflammatory index and neutrophil-lymphocyte ratio, hyponatremia, hypochloremia and elevated levels of AST, ALT, LDH and CRP may help healthcare providers in early identification of COVID-19 patients. Healthy controls were superior to COVID-like controls since they provided better insight into the laboratory characteristics of children with novel betacoronavirus (SARS-CoV-2) infection.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Baseline laboratory parameters for preliminary diagnosis of COVID-19 among children: a cross-sectional study

et al. 2022

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“…Additionally, a control group would enable researchers to investigate potential risk factors or associations contributing to the development of ptosis, enhancing the depth of the study’s analysis. 4 , 5 …”

Section: Dear Editormentioning

confidence: 99%

The Prevalence and Severity of Acquired Blepharoptosis in US Eye Care Clinic Patients and Their Receptivity to Treatment [Letter]

Rajput,

Mahawar,

Singh

2024

OPTH

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“…Misidentifying a study can either over or under-label the level of evidence 17 . A recent review of articles published in the Journal of Neurosurgery showed that only 48% of those touted as case-control were truly case-control studies, showing a high rate of misidentifying study type 33,34 . Accurate reporting and reader understanding of a given study design is not only important for LOE reporting but affects the strength of study conclusions/findings and overall validity.…”

Section: Introductionmentioning

confidence: 99%

Evidence-Based Medicine and Observational Studies

Meade,

Buchan,

Stark

et al. 2023

Clinical Spine Surgery: A Spine Publication

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Evidence-based medicine drives medical decision-making in the modern era, which has historically favored randomized control trials. Despite their notoriety, randomized control trials have multiple disadvantages when applied to spinal surgery. Observational studies are popular in spinal surgery literature and are seen in various forms, such as retrospective studies and prospective cohort studies. For researchers, learners, and practicing spine surgeons, this paper describes options for study design when applied to spinal surgery.

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Grab Control! Choosing the Right Comparison Group in an Observational Study

Cited by 4 publications

References 8 publications

Baseline laboratory parameters for preliminary diagnosis of COVID-19 among children: a cross-sectional study

Baseline laboratory parameters for preliminary diagnosis of COVID-19 among children: a cross-sectional study

The Prevalence and Severity of Acquired Blepharoptosis in US Eye Care Clinic Patients and Their Receptivity to Treatment [Letter]

Evidence-Based Medicine and Observational Studies

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