“…The area of medical image processing and analysis has contributed to significant medical advances [7,23,50,81,83,88,101] by integrating systems and techniques that support more efficient clinical diagnosis. These systems and techniques are based on images acquired by different imaging modalities such as, endoscopy [52], X-ray [88], microscopy [47,68], computed tomography (CT) [26,57], optical coherence tomography (OCT) [67], magnetic resonance (MR) [2,15], functional magnetic resonance (fMR) [3,97], magnetic resonance elastography (MRE) [20], positron emission tomography (PET) [17,42,43], single photon emission computed tomography (SPECT) [28], and 3D ultrasound computer tomography (USCT) [7].…”