GPU-accelerated scanning path optimization in particle cancer therapy

Wu, Chao; Pu, Yunjiao; Zhang, Xiao

doi:10.1007/s41365-019-0582-6

Cited by 3 publications

(2 citation statements)

References 14 publications

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“…For a more accurate assessment of the raster scanning technique, a detailed spill structure should be considered in the scanning simulation. Furthermore, path optimization [28] was not performed for the clinical case in this study. In other words, integrating path optimization into the treatment plan design is likely to generate more spots with sufficient overlapping and meet the feasibility requirement.…”

Section: Irradiation Of Pelvic Region Casementioning

confidence: 99%

Shortening the delivery time of proton therapy by real-time compensation method with raster scanning

Sun

Li²,

Liu

et al. 2022

NUCL SCI TECH

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Among the various scanning techniques, spot and raster scanning are the most frequently adopted. Raster scanning turns off the beam only when each isoenergy slice irradiation is completed. This feature intrinsically solves the leakage dose and frequent beam-switching problems encountered during spot scanning. However, to shorten the delivery time of raster scanning, a sophisticated dose control strategy is required to guarantee dose distribution. In this study, a real-time compensation method with raster scanning for synchrotron systems was designed. It is characterized by a small spot-spacing planning strategy and real-time subtraction of the transient number of particles delivered between two planning-spot positions from the planned number of particles of the subsequent raster point. The efficacy of the compensation method was demonstrated by performing accurate raster scanning simulations with an in-house simulation code and accurate final dose evaluations with a commercial treatment planning system. Given the similar dose evaluation criteria under a practical high scanning speed, compared with the spot scanning method, the total delivery time of the compensated raster scanning method was significantly shortened by 53.3% in the case of irradiating a cubical target and by 28.8% in a pelvic case. Therefore, it can be concluded that real-time compensated raster scanning with a fast scanning configuration can significantly shorten the delivery time compared to that of spot scanning. It is important to reduce the pressure on patients caused by prolonged immobilization and to improve patient throughput capacity at particle therapy centers.

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Section: Irradiation Of Pelvic Region Casementioning

confidence: 99%

Shortening the delivery time of proton therapy by real-time compensation method with raster scanning

Sun

Li²,

Liu

et al. 2022

NUCL SCI TECH

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“…In addition, shortening the treatment time is also an important criteria for the physical burden of the patient, and decreasing the number of spots directly contributes to the treatment time reduction. By using heuristic approaches such as simulated annealing, several researchers addressed proposing the scan path optimization technique to find the best order of spots to be irradiated for minimizing the total path length of the beam motion (Kang et al, 2007;Wu et al, 2019). In these studies, however, the spot positions were still fixed with the lattice pattern and the number of spots was also fixed.…”

Section: Introductionmentioning

confidence: 99%

Layout optimization of the beam spot locations scanned by electromagnets in particle beam therapy

Sakamoto

NAGASHIMA

Sato

et al. 2022

Mechanical Engineering Journal

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This paper presents a layout optimization method of the spot locations of pencil beam scanning for particle beam cancer therapy. With the pencil beam scanning technique, the particle beam is scanned from spot to spot in the tumor by using scanning magnets. To provide clinically ideal dose distributions and less-invasive treatment to the patients, both the spot locations and the number of particles given to each spot should be optimized. However, the spot layout is fixed with a lattice pattern in many prior studies. We propose the optimization method to derive the non-lattice spot layout to realize an acceptable dose distribution with a reduced number of spots. With the proposed method, a large enough number of spots were located densely at the initial state, and then the spots with the smallest contribution were removed one by one through iterations. The number of particles given to each spot was determined by solving a quadratic problem. Furthermore, we also propose the idea to accelerate the optimization process by simultaneously removing multiple spots. The algorithm was confirmed by numerical examples of both two-dimensional and three-dimensional cases. The dose quality with the optimized spot layout was better than that with the conventional lattice spot patterns, with all tested cases. In the optimized spot layout, the spots were located on the closed lines which were concentric to the target contour. We also confirmed the proposed method of multiple-remotion can accelerate the optimization process without violating the dose quality.

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