GPRC5B protects osteoarthritis by regulation of autophagy signaling

Liang, He; Xu, Ziwei; Niu, Xin; Li, Rong; Wang, Fanhua; You, Yu; Gao, Jingduo; Zhao, Lei; Shah, Karan M.; Fan, Jie; Liu, Mingyao; Luo, Jian

doi:10.1016/j.apsb.2023.05.014

Cited by 4 publications

(2 citation statements)

References 50 publications

(51 reference statements)

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“… 176 , 177 Proteins such as PGRN and G protein-coupled receptor family C group 5 member B (GPRC5B) play roles in maintaining chondrocyte health through their involvement in autophagy. 178 , 179 Moderate mechanical strain can promote the restoration of metabolic homeostasis by inhibiting inflammation and excessive autophagy.…”

Section: Autophagy In Bone Metabolismmentioning

confidence: 99%

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Epigenetic Regulation of Autophagy in Bone Metabolism

Zhang,

Wang,

Xue

et al. 2024

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The skeletal system is crucial for supporting bodily functions, protecting vital organs, facilitating hematopoiesis, and storing essential minerals. Skeletal homeostasis, which includes aspects like bone density, structural integrity, and regenerative processes, is essential for normal skeletal function. Autophagy, an intricate intracellular mechanism for degrading and recycling cellular components, plays a multifaceted role in bone metabolism. It involves sequestering cellular waste, damaged proteins, and organelles within autophagosomes, which are then degraded and recycled. Autophagy's impact on bone health varies depending on factors such as regulation, cell type, environmental cues, and physiological context. Despite being traditionally considered a cytoplasmic process, autophagy is subject to transcriptional and epigenetic regulation within the nucleus. However, the precise influence of epigenetic regulation, including DNA methylation, histone modifications, and non-coding RNA (ncRNA) expression, on cellular fate remains incompletely understood. The interplay between autophagy and epigenetic modifications adds complexity to bone cell regulation. This article provides an in-depth exploration of the intricate interplay between these two regulatory paradigms, with a focus on the epigenetic control of autophagy in bone metabolism. Such an understanding enhances our knowledge of bone metabolism-related disorders and offers insights for the development of targeted therapeutic strategies.

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Section: Autophagy In Bone Metabolismmentioning

confidence: 99%

“…Conversely, demethylation enhances autophagy, showing therapeutic potential in cancer treatments. 176 , 178 , 179 Additionally, in conditions like osteoporosis and osteoarthritis, abnormal DNA methylation affects autophagy, highlighting its role in bone health. 180 …”

Section: Epigenetic Regulation Of Autophagy In Bone Metabolismmentioning

confidence: 99%