GPR68 activated transmembrane to cytosol growth-based visual learning based on Prefrontal Cortex big data

Abstract

G protein-coupled receptor (GPR68) is widely distributed in the human body and participates in various physiological and pathological processes. The main GPR68-activated and -inhibited molecular network was constructed in Prefrontal Cortex by integrating SAM, SPSS Pearson and GRNInfer mutual positive verification based on richness. The main GPR68 activated molecular subnetwork composed of upstream KCNKpotassium ion transmembrane transport, feedback MAP1B_2-cytosol microtubule binding, and downstream NDRG4-cytosol growth-based visual learning in Prefrontal Cortex. The main GPR68 inhibited subnetwork included upstream PKP4 with TMEM63A-extracellular exosome nucleotide binding in Prefrontal Cortex by DAVID. The relationship of PKP4 activation to TMEM63A was found in Prefrontal Cortex for positive main molecular verification. The relationship of NDRG4 inhibition to TMEM63A -> KCNK1 -> PKP4 in Prefrontal Cortex for negative main molecular verification. The main GPR68-activated and -inhibited model was positive verified by the corresponding other similar and common knowledge. We put forwards the model in Prefrontal Cortex that GPR68 activated cytosol microtubule binding coupling potassium ion transmembrane transport to cytosol growth-based visual learning with 18-inhibited model for mutual negative knowledge verification. The role and mechanism of GPR68 activated transmembrane to cytosol growth-based visual learning based on Prefrontal Cortex big data contribute to better detection, evaluation, intervention, tracking, and other health management of brain diseases.