Abstract:Background and Purpose: GPR55 is a G protein-coupled receptor that
recognizes several lipid molecules. GPR55 expression in human monocytes
and its proinflammatory role lead us to investigate the role of GPR55 in
monocyte adhesion and atherosclerosis development. Experimental
Approach: We investigated monocyte adhesion in human THP-1 monocytes and
atherosclerosis development in ApoE-/- mice by using O-1602 (a potent
agonist of GPR55), CID16020046 (a specific GPR55 antagonist), and a
high-fat diet-induced athero… Show more
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