GPR17 expressing NG2‐Glia: Oligodendrocyte progenitors serving as a reserve pool after injury

Viganò, Francesca; Schneider, Sarah; Cimino, Mauro; Bonfanti, Elisabetta; Gelosa, Paolo; Sironi, Luigi; Abbracchio, Maria P.; Dimou, Leda

doi:10.1002/glia.22929

Cited by 69 publications

(101 citation statements)

References 30 publications

(100 reference statements)

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“…Following chronic stress, NG2-glia have been shown to upregulate death receptor 6 expression, a TNFα receptor upstream of JNK and NF-κB pathways [106]. (3) G-coupled protein 17 (GFPR17) expressed by a subset of NG2-glia has also been suggested to act as a molecular sensor to environmental insults [107] and might play a role in stress sensing in the adult CNS. (4) GSK3 is a fundamental signaling hub in oligodendrocytes which integrates key processes as metabolism, inflammation and myelination [108].…”

Section: Association Of Ng2-glia With Neuropsychiatric Disordersmentioning

confidence: 99%

Oligodendroglia-lineage cells in brain plasticity, homeostasis and psychiatric disorders

Birey

Kokkosis

Aguirre

2017

Current Opinion in Neurobiology

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Adult oligodendrocyte progenitor cells are uniformly distributed in both gray and white matter, displaying robust proliferative and migratory potential during health and disease. Recently, developments in new experimental approaches have brought about several novel insights about NG2-glia and myelinating oligodendrocytes, indicating a diverse toolkit of functions in experience-dependent myelination and homeostasis in the adult CNS. In this review, we summarize some of the topical studies that highlight newly emerging findings that implicate oligodendroglia-lineage cells in brain plasticity, homeostasis and pathophysiology of neuropsychiatric disorders.

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Section: Association Of Ng2-glia With Neuropsychiatric Disordersmentioning

confidence: 99%

Oligodendroglia-lineage cells in brain plasticity, homeostasis and psychiatric disorders

Birey

Kokkosis

Aguirre

2017

Current Opinion in Neurobiology

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“…Importantly, GPR17-expressing OPCs serve as a reserve pool for tissue repair after brain damage (15). GPR17-positive OPCs rapidly react to the damage and undergo maturation in a mouse model of cerebral injury and ischemia (15).…”

Section: Quantification Of Gpr17 Immunoreactive Cellsmentioning

confidence: 99%

“…GPR17-positive OPCs rapidly react to the damage and undergo maturation in a mouse model of cerebral injury and ischemia (15). The GPR17 agonist UDP-glucose promotes the recovery of myelination in ischemic periventricular leukomalacia (PVL), a rat model of cerebral white matter injury (16), suggesting that GPR17 activation facilitates myelination in vivo.…”

Section: Quantification Of Gpr17 Immunoreactive Cellsmentioning

confidence: 99%

Expression of GPR17, a regulator of oligodendrocyte differentiation and maturation, in Nasu-Hakola disease brains

Satoh

Kino

Yanaizu

et al. 2017

IRDR

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“…For example, GPR126/ ADGRG6 could be targeted in the PNS, perhaps by a modified Stachel-sequence peptide [20], to promote myelination in MDC1A, as these patients lack functional laminin-211 ligand but should possess GPR126/ADGRG6 in Schwann cells. In the CNS, Gpr17 has been explored as a potential therapeutic target in remyelination either by inhibiting Gpr17 via antagonists or by activating the reserve pool of Gpr17-expressing OPCs to maturation [79,80]. As Gpr17 is enriched in white matter plaques of MS patients and in rodent models of MS, antagonism of Gpr17 or other inhibitory GPCRs may indeed be efficacious in future treatment strategies [57,64,66,67].…”

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confidence: 99%

G Protein-Coupled Receptors in Myelinating Glia

Mogha¹,

D’Rozario²,

Monk

2017

Trends in Pharmacological Sciences

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The G protein-coupled receptor (GPCR) super-family represents the largest class of functionally selective drug targets for disease modulation and therapy. GPCRs have been studied in great detail in central nervous system (CNS) neurons, yet these important molecules have been relatively understudied in glia. In recent years, however, exciting new roles for GPCRs in glial cell biology have emerged. Here, we focus on key roles for GPCRs in a specialized subset of glia, myelinating glia. We highlight recent work firmly establishing GPCRs as regulators of myelinating glial cell development and myelin repair. These advancements expand our understanding of myelinating glial cell biology and underscore the utility of targeting GPCRs to promote myelin repair in human disease. KeywordsG protein-coupled receptor (GPCR); myelination; Schwann cell; oligodendrocyte; remyelination An overview of G protein-coupled receptors in the nervous systemThe G protein-coupled receptor (GPCR) super-family of seven transmembrane (7TM) receptors comprises the largest class of cell membrane receptors [1]. GPCRs are activated by myriad stimuli including peptides, hormones, light, proteolytic processing of their Ntermini, small molecules, and more traditional protein ligands [2,3]. GPCRs have emerged as major pharmacological drug targets due to their key roles in a variety of physiological functions in disease and health, and GPCR modulators represent at least one-third of all clinically marketed drugs [4]. GPCRs can be classified into five families using the phylogenetically based GRAFS system: glutamate, rhodopsin, adhesion, frizzled, and secretin [5]. Glutamate is a major excitatory neurotransmitter in the nervous system, and * Correspondence: monkk@wustl.edu (K.R. Monk). Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Conflict of interest statementThe authors declare no competing conflicts. HHS Public Access Author ManuscriptAuthor Manuscript Author ManuscriptAuthor Manuscript accordingly, glutamate receptors have been studied in great detail with regard to their key roles in synaptic transmission, synapse formation, axon guidance, and development of neuronal circuits [6,7]. The rhodopsin family has by far the greatest number of GPCRs, and members are involved in photoreception and neurotransmission [5]. Frizzled GPCRs are activated by wingless/int (Wnt) proteins and control numerous cellular processes including neural crest development, patterning and adult neurogenesis [8]. Secretin receptors are classic hormone receptors, some of which have neuroprotective functions in the central nervou...

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GPR17 expressing NG2‐Glia: Oligodendrocyte progenitors serving as a reserve pool after injury

Cited by 69 publications

References 30 publications

Oligodendroglia-lineage cells in brain plasticity, homeostasis and psychiatric disorders

Oligodendroglia-lineage cells in brain plasticity, homeostasis and psychiatric disorders

Expression of GPR17, a regulator of oligodendrocyte differentiation and maturation, in Nasu-Hakola disease brains

G Protein-Coupled Receptors in Myelinating Glia

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