Gpr125 Marks Distinct Cochlear Cell Types and Is Dispensable for Cochlear Development and Hearing

Sun, Haiying; Atkinson, Patrick; Billings, Sara E.; Dong, Wei; Cheng, Alan G.

doi:10.3389/fcell.2021.690955

Cited by 2 publications

(2 citation statements)

References 42 publications

(64 reference statements)

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“…G protein-coupled receptor 125 (GPR125) is also named as adhesion G protein-coupled receptor A3 (ADGRA3), and involve in regulating planar cell polarity signaling ( Li et al, 2013 ). GPR125 is widely expressed in the cochlea, especially in OHCs, SGNs, and interdental cells (ICs) ( Sun et al, 2021 ). However, in GP125-deficient mice, various types of cells developed normally, and hearing function was not impaired ( Sun et al, 2021 ), implying that GPR125 may not regulate the planar cell polarity in the cochlea.…”

Section: Roles Of Class B2 G Protein-coupled Receptors In Cochleamentioning

confidence: 99%

“…GPR125 is widely expressed in the cochlea, especially in OHCs, SGNs, and interdental cells (ICs) ( Sun et al, 2021 ). However, in GP125-deficient mice, various types of cells developed normally, and hearing function was not impaired ( Sun et al, 2021 ), implying that GPR125 may not regulate the planar cell polarity in the cochlea.…”

Section: Roles Of Class B2 G Protein-coupled Receptors In Cochleamentioning

confidence: 99%

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G protein-coupled receptors in cochlea: Potential therapeutic targets for hearing loss

Guo²,

Fu³

et al. 2022

Front. Mol. Neurosci.

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The prevalence of hearing loss-related diseases caused by different factors is increasing worldwide year by year. Currently, however, the patient’s hearing loss has not been effectively improved. Therefore, there is an urgent need to adopt new treatment measures and treatment techniques to help improve the therapeutic effect of hearing loss. G protein-coupled receptors (GPCRs), as crucial cell surface receptors, can widely participate in different physiological and pathological processes, particularly play an essential role in many disease occurrences and be served as promising therapeutic targets. However, no specific drugs on the market have been found to target the GPCRs of the cochlea. Interestingly, many recent studies have demonstrated that GPCRs can participate in various pathogenic process related to hearing loss in the cochlea including heredity, noise, ototoxic drugs, cochlear structure, and so on. In this review, we comprehensively summarize the functions of 53 GPCRs known in the cochlea and their relationships with hearing loss, and highlight the recent advances of new techniques used in cochlear study including cryo-EM, AI, GPCR drug screening, gene therapy vectors, and CRISPR editing technology, as well as discuss in depth the future direction of novel GPCR-based drug development and gene therapy for cochlear hearing loss. Collectively, this review is to facilitate basic and (pre-) clinical research in this area, and provide beneficial help for emerging GPCR-based cochlear therapies.

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Section: Roles Of Class B2 G Protein-coupled Receptors In Cochleamentioning

confidence: 99%

Section: Roles Of Class B2 G Protein-coupled Receptors In Cochleamentioning

confidence: 99%

G protein-coupled receptors in cochlea: Potential therapeutic targets for hearing loss

Guo²,

Fu³

et al. 2022

Front. Mol. Neurosci.

View full text Add to dashboard Cite

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Hear the sounds: the role of G protein-coupled receptors in the cochlea

Zhang

Chai

2022

American Journal of Physiology-Cell Physiology

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Sound is converted by hair cells in the cochlea into electrical signals, which are transmitted by spiral ganglion neurons (SGNs) and heard by the auditory cortex. G protein-coupled receptors (GPCRs) are crucial receptors that regulate a wide range of physiological functions in different organ and tissues. The research of GPCRs in the cochlea is essential for the understanding of the cochlea development, hearing disorders, and the treatment for hearing loss. Recently, several GPCRs have been found to play important roles in the cochlea. Frizzleds and Lgrs are dominant GPCRs that regulate stem cell self-renew abilities. Moreover, Frizzleds and Celsrs have been demonstrated to play core roles in the modulation of cochlear planar cell polarity (PCP). In addition, hearing loss can be caused by mutations of certain GPCRs, such as Vlgr1, Gpr156, S1P2 and Gpr126. And A1, A2A and CB2 activation by agonists have protective functions on noise- or drug-induced hearing loss. Here, we review the key findings of GPCR in the cochlea, and discuss the role of GPCR in the cochlea, such as stem cell fate, PCP, hearing loss, and hearing protection.

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Gpr125 Marks Distinct Cochlear Cell Types and Is Dispensable for Cochlear Development and Hearing

Cited by 2 publications

References 42 publications

G protein-coupled receptors in cochlea: Potential therapeutic targets for hearing loss

G protein-coupled receptors in cochlea: Potential therapeutic targets for hearing loss

Hear the sounds: the role of G protein-coupled receptors in the cochlea

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