GPER1 Activation Exerts Anti-Tumor Activity in Multiple Myeloma
Maria Eugenia Gallo Cantafio,
Roberta Torcasio,
Francesca Scionti
et al.
Abstract:G protein-coupled estrogen receptor 1 (GPER1) activation is emerging as a promising therapeutic strategy against several cancer types. While GPER targeting has been widely studied in the context of solid tumors, its effect on hematological malignancies remains to be fully understood. Here, we show that GPER1 mRNA is down-regulated in plasma cells from overt multiple myeloma (MM) and plasma cell leukemia patients as compared to normal donors or pre-malignant conditions (monoclonal gammopathy of undetermined sig… Show more
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