Governing the aggregation of type I collagen mediated through β-cyclodextrin

Ding, Chaoliang; Tian, Mengdie; Wang, Yue; Cheng, Kang; Yi, Yifan; Zhang, Min

doi:10.1016/j.ijbiomac.2023.124469

Cited by 4 publications

(2 citation statements)

References 33 publications

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“…The fibrillar architecture consisted of Type I collagen serves as the structure foundation of ECMs and endowed ECMs with viscoelasticity, , which has gained extensive attention in the field of developing ECM analogues with stress relaxation behaviors. − The viscoelasticity property of collagen was closely linked to its self-assembly behavior, which was controlled by such factors as temperature, pH, and the addition of polymers/inorganics. , For example, Su et al introduced alginate with varying molecular weights during the collagen fibrillogenesis process to tune the stress relaxation of the resulting matrices . Fan et al introduced a reversible covalent bond into collagen hydrogels to achieve the regulation of the stress relaxation rate .…”

Section: Introductionmentioning

confidence: 99%

“…12−16 The viscoelasticity property of collagen was closely linked to its self-assembly behavior, which was controlled by such factors as temperature, pH, and the addition of polymers/inorganics. 17,18 For example, Su et al introduced alginate with varying molecular weights during the collagen fibrillogenesis process to tune the stress relaxation of the resulting matrices. 19 covalent bond into collagen hydrogels to achieve the regulation of the stress relaxation rate.…”

Section: ■ Introductionmentioning

confidence: 99%

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Tunable Stress Relaxing Biomimetic Matrices: Hyaluronan/Hydroxyapatite Hybridization Mediates Assembly of Collagen Fibrils

Tan,

Ma,

Cao

et al. 2023

Biomacromolecules

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The alluring correlations of cellular behaviors with viscoelastic extracellular matrices have driven increasing endeavors directed toward the understanding of mechanical cues on cell growth and differentiation via preparing biomimetic scaffolds/gels with viscoelastic controllability. Indeed, systematic investigations, especially into calcium phosphate-containing biomimetics, are relatively rare. Here, oxidized hyaluronic acid/hydroxyapatite hybrids (OHAHs) were synthesized by hyaluronan-mediated biomimetic mineralization with confined ion diffusion and subsequent oxidization treatment. The collagen self-assembly was applied to fabricate tunable stress relaxing fibrillar matrices in the presence of OHAHs in which the incorporated hyaluronic acid with aldehyde groups acted to improve the component compatibility as well as to supplement the molecular interactions with the occurrence of a Schiff-base reaction. With the addition of varying OHAH contents, the self-assembly behavior of collagen was altered, and the obtained collagen-hybrid (CH) matrices presented a heterogeneous fibrillar structure interspersed with OHAHs, characterized by large fibrillar bundles coexisting with small fibrils. The OHAHs improved the hydrogel stability of pure collagen, and according to rheological and nanoindentation measurements, CH matrices also exhibited tunable stress relaxation rates, following an OHAH concentration-dependent fashion. The proliferation and spreading of MC3T3-E1 cells cultured onto such CH matrices were further found to increase with the stress relaxing rate of the matrices. The present study showed that the introduction of hydroxyapatite incorporated with active hyaluronic acid during collagen reconstitution was a simple and effective strategy to realize the preparation of tunable stress relaxing biomimetic matrices potentially used for further appraising the regulation of mechanical cues on cell behaviors.

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