Governance, expertise, and the ‘culture of care’: The changing constitutions of laboratory animal research in Britain, 1876–2000

Kirk, Robert; Myelnikov, Dmitriy

doi:10.1016/j.shpsa.2022.03.004

Cited by 7 publications

(8 citation statements)

References 23 publications

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“…The responsibility and stability modes are, we propose, unique to the world of mouse genetics. Freezing was part of the moral management strategy in the 1990s UK, specific to the country’s late-twentieth-century regulatory arrangements and the cultural concerns over animal experimentation ( Friese, Nuyts, and Pardo-Guerra 2019 ; Kirk and Myelnikov 2022 ). It also, however, shifted the usual cryopolitical logic.…”

Section: Discussionmentioning

confidence: 99%

“…In the UK, the Animals (Scientific Purposes) Act 1986 (ASPA) replaced the Victorian Cruelty to Animals Act 1876 that had governed experimentation for over a century of dramatic scientific change. Designed as a compromise between scientific interests, moderate welfare campaigners, and the regulatory needs of the Home Office, ASPA revised the system of licensing for animal experiments, covered a broader range of procedures (including breeding), and empowered veterinarians, animal technicians, and selected lay voices ( Kirk and Myelnikov 2022 ).…”

Section: Introductionmentioning

confidence: 99%

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The Cold Futures of Mouse Genetics: Modes of Strain Cryopreservation Since the 1970s

Myelnikov

Peres

2022

Science, Technology, & Human Values

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Cryopreservation, or the freezing of embryos or sperm, has become a routine part of many research projects involving laboratory mice. In this article, we combine historical and sociological methods to produce a cryopolitical analysis of this less explored aspect of animal research. We provide a longitudinal account of mouse embryo and semen storage and uses in the UK and show that cryopreservation enabled researchers to overcome particular challenges—fears of strain loss, societal disapproval, and genetic drift—in ways which enabled the continued existence of strains and contributed to the scaling up of mouse research since World War II. We use the theoretical lens of cryopolitics to explore three different, yet overlapping, cryopolitical strategies that we identify. All share the ability to ensure the continued maintenance of genetically defined strains without the need for continually breeding colonies of mice. We argue that, in contrast to more common imaginaries of species conservation, the cryopolitical rationale can best be understood as purposefully not letting the strain die without requiring animals to live. The ability to freeze mice, then, had the potential to unsettle who the objects of care are in mouse research, from individual animals to the concept of the strain itself.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Cold Futures of Mouse Genetics: Modes of Strain Cryopreservation Since the 1970s

Myelnikov

Peres

2022

Science, Technology, & Human Values

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“…30 The figure of the veterinarian -what became known as a Named Veterinary Surgeon (NVS) -was a compromise that appealed to many parties, including the various representatives of the profession. 31 To CRAE, they were potential 'animal friends', there on behalf of the animals. 32 The BVA members also allowed the triple alliance to boost its scientific authority over a key point -the interpretation of pain in experiments.…”

Section: The Triple Alliancementioning

confidence: 99%

“…Veterinarians, animal technicians, and moderate welfare advocates acquired a degree of expertise, control, and responsibility. 47 Several issues took centre stage in the discussions of the White Paper and subsequent responses to it in drafting legislation. Some of the key features were largely well-received, notably the threepart licensing system, which required licences for an individual as a competent experimenter, for the institution and facilities where the research took place, and, crucially, for the actual project as being justified on scientific grounds and in its experimental design.…”

Section: Curating the Consensus: Inclusions And Exclusions At The Hom...mentioning

confidence: 99%

1 A ‘fragile consensus’? The origins of the Animals (Scientific Procedures) Act 1986

Myelnikov

2024

Researching Animal Research

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“…An in-depth discussion on these issues is beyond the scope of this review and are well summarized elsewhere( 11 – 13 ). However, it is important to highlight that statutory and regulatory frameworks have improved practice globally.…”

Section: Introductionmentioning

confidence: 99%

State-of-the-art review and update of in vivo models of necrotizing enterocolitis

et al. 2023

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NEC remains one of the most common causes of mortality and morbidity in preterm infants. Animal models of necrotizing enterocolitis (NEC) have been crucial in improving our understanding of this devastating disease and identifying biochemical pathways with therapeutic potential. The pathogenesis of NEC remains incompletely understood, with no specific entity that unifies all infants that develop NEC. Therefore, investigators rely on animal models to manipulate variables and provide a means to test interventions, making them valuable tools to enhance our understanding and prevent and treat NEC. The advancements in molecular analytic tools, genetic manipulation, and imaging modalities and the emergence of scientific collaborations have given rise to unique perspectives and disease correlates, creating novel pathways of investigation. A critical review and understanding of the current phenotypic considerations of the highly relevant animal models of NEC are crucial to developing novel therapeutic and preventative strategies for NEC.

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Governance, expertise, and the ‘culture of care’: The changing constitutions of laboratory animal research in Britain, 1876–2000

Cited by 7 publications

References 23 publications

The Cold Futures of Mouse Genetics: Modes of Strain Cryopreservation Since the 1970s

The Cold Futures of Mouse Genetics: Modes of Strain Cryopreservation Since the 1970s

1 A ‘fragile consensus’? The origins of the Animals (Scientific Procedures) Act 1986

State-of-the-art review and update of in vivo models of necrotizing enterocolitis

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