“…The cytologic findings of gouty tophus have been described by Liu et al 19 and Nicol et al 20 Confirmation under polarization and compensated polarized microscopy is essential to reach a precise diagnosis and to rule out other entities containing polarizable crystals. 19 In an aspirate of a nodular mass located in the hand and containing metachromatic stroma, if calcium, osteoid, and cartilage can be safely ruled out, the diagnosis of gout should be entertained.…”
“…The cytologic findings of gouty tophus have been described by Liu et al 19 and Nicol et al 20 Confirmation under polarization and compensated polarized microscopy is essential to reach a precise diagnosis and to rule out other entities containing polarizable crystals. 19 In an aspirate of a nodular mass located in the hand and containing metachromatic stroma, if calcium, osteoid, and cartilage can be safely ruled out, the diagnosis of gout should be entertained.…”
“…[2], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21 ], [22], [23] Details of these are shown in ( …”
Section: Discussionmentioning
confidence: 99%
“…Rege et al [21] 2000 2 -Nodules on bilateral malleoli -Nodules on dorsum foot, sole, lateral malleoli -Arthritis -Gout Nicol et al [2] 1997 3 -Dorsal ulnar, right distal forearm -1 st and 3 rd metacarpal joints -Right foot and ankle -Sarcoma -Gout -Sarcoma Lieu et al [22] 1996 1 Right distal ulnar mass GCT Nasser et al [23] 1994 2 -Vertebral level, C3, C4 -Forearm nodule -Not given -Not given…”
Fine needle aspiration cytology (FNAC) is a valuable diagnostic tool for the diagnosis of periarticular nodules. We present a case of forty five year old male with multiple soft tissue nodules on both the feet without any clinical and radiological features of arthritis. FNAC revealed needle shaped crystals consistent with monosodium urate crystals in amorphous granular debris. Diagnosis of gouty tophi was given. On follow up serum uric acid levels were found to be marginally high and a diagnosis of gout was established. FNAC is a valuable diagnostic tool for the diagnosis of periarticular nodules and pathologists should be aware of cytological features of gouty tophi.Keywords: FNAC, gouty tophi, monosodium urate crystals, uric acid Introduction:
“…The aspiration of unusual deposits, such as tophi, may also be performed for diagnostic microscopy. 9 The imaging of tophi is more variable than may be expected of calcium-containing deposits. Gerster et al 6 report on the use of computed tomography for intra-articular tophi of the knee, but outside of the knee, most reports comment on the use of MRI.…”
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