Gouty arthritis at interphalangeal joint of foot after sildenafil use: A case report

Alıcı, Tuğrul; İmren, Yunus; Erdil, Mehmet; Gundes, Hakan

doi:10.1016/j.ijscr.2012.08.014

Cited by 9 publications

(9 citation statements)

References 7 publications

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“…Following surgical decompression, pharmacological treatment and lifestyle modifications are of paramount importance. 5 In our report, there was a chronic gout case refractory to the treatment. Skin ulceration and discharge developed, and the patient significantly benefited from the surgical decompression and pharmacological treatment.…”

Section: Discussionmentioning

confidence: 59%

“…Although the triggering mechanism of the acute attack has been poorly understood, factors for the development of gout have been described (4). These include an increased level of uric acid, alcohol abuse, hypertension, the use of antihypertensives, increased body mass index (BMI) and familial history of gout (5). In addition, it has been reported that gout may be associated with persistent psoriasis especially in male patients and in those with other causes of hyperuricemia (6).…”

mentioning

confidence: 99%

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Psoriasis Related Gout Arthritis In The Big Toe Interphalangeal Joint: A Case Report

Öztürk¹

2020

Acibadem Universitesi Saglik Bilimleri Dergisi

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In this study, we present the first report of a case of gout arthritis localized in the interphalangeal joint of the right foot first toe, which was related to psoriasis disease in a 40-year-old male patient. Since the symptoms did not respond to conservative treatments, the patient was treated with surgery. Arthrotomy was performed to debride around the bones and intraarticular crystals. Then, pharmacological treatment was initiated and lifestyle changes were made. No recurrence of the symptoms was observed during a 24-month follow-up.

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Section: Discussionmentioning

confidence: 59%

mentioning

confidence: 99%

Psoriasis Related Gout Arthritis In The Big Toe Interphalangeal Joint: A Case Report

Öztürk¹

2020

Acibadem Universitesi Saglik Bilimleri Dergisi

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“…It is also worth mentioning that two case reports of acute gouty arthritis occurring following intake of sildenafil [ 130 , 131 ], a phosphodiesterase type 5 inhibitor (PDE5i), used in the treatment of erectile dysfunction. While these case reports have been extraordinarily rare, and more studies are therefore needed in these regards, this evidence should drive clinicians toward careful use of PDE5i in patients with gout, or possibly even asymptomatic hyperuricemia.…”

Section: Resultsmentioning

confidence: 99%

Relationship between hyperuricemia with deposition and sexual dysfunction in males and females

Sansone

Reisman

Jannini

2022

J Endocrinol Invest

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Purpose The association between gout, the most common crystal arthropathy, and sexual dysfunctions has often been investigated by studies in the last decades. Despite the presence of shared risk factors and comorbidities and the possible effects on sexual health of long-term gout complications, awareness of this association is severely lacking and the pathogenetic mechanisms have only partially been identified. In the present review, we aimed to investigate the current evidence regarding the potential mechanisms linking sexual dysfunctions and gout. Methods A comprehensive literature search within PubMed was performed to provide a summary of currently available evidence regarding the association between gout and sexual dysfunctions. Results Gout and sexual dysfunctions share several risk factors, including diabesity, chronic kidney disease, hypertension, metabolic syndrome, and peripheral vascular disease. Gout flares triggered by intense inflammatory responses feature severe pain and disability, resulting in worse sexual function, and some, but not all, treatments can also impair sexual health. Long-term gout complications can result in persistent pain and disability due to joint deformity, fractures, or nerve compression, with negative bearing on sexual function. The presence of low-grade inflammation impairs both sex steroids synthesis and endothelial function, further advancing sexual dysfunctions. The psychological burden of gout is another issue negatively affecting sexual health. Conclusions According to currently available evidence, several biological and psychological mechanisms link sexual dysfunctions and gout. Addressing risk factors and providing adequate treatment could potentially have beneficial effects on both conditions. Appropriate clinical evaluation and multidisciplinary approach are recommended to improve patient care.

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“…It was hypothesized that her pregnancy resulted in insulin resistance, reducing the renal excretion of urate, and eventually provoked the flare. Alici et al [14] presented a case of a 58-year-old hypertensive man with several episodes of pain and swelling in the first interphalangeal joint of the right great toe. The appearance and recurrence of symptoms occurred after sildenafil was used, and there were no symptoms after withdrawal of the drug.…”

Section: Discussionmentioning

confidence: 99%

“…According to the available literature [10][11][12][13][14][15][16][17][18][19], gouty arthritis usually occurs in patients with hyperuricemia and it can be induced by a variety of factors. Here, we describe a case of acute gouty arthritis attacks caused by a great toe injury, which was successfully treated with benzbromarone and ibuprofen.…”

Section: Introductionmentioning

confidence: 99%

Acute gouty arthritis attacks induced by a great toe injury: a case report and literature review

2022

MEDSC

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Introduction: Gouty arthritis usually occurs in patients with hyperuricemia and can be induced by a variety of factors. Here, we describe a case of acute gouty arthritis attacks induced by a great toe injury and was successfully treated by benzbromarone and ibuprofen. Patient concerns: A 27-year-old Asian man with hyperuricemia informed us his first metatarsophalangeal joint of left foot began to redness and swelling, accompanied by severe pain presented 8 days after the toenail injury. Diagnoses: Laboratory tests confirmed as gouty arthritis with no signs of infection, but serum uric acid was significantly higher than normal at 523 μmol/L. Interventions: Drug treatment was adopted, including benzbromarone 100 mg daily, ibuprofen pills 75mg twice a day, and sodium bicarbonate tablets 0.5g three times a day. Outcomes: All of his symptoms of acute gouty arthritis attacks gradually disappear after drug treatment for a week and blood uric acid had dropped to 87 μmol/L two weeks later. Conclusion: When patients with a broken great toe present with symptoms of first metatarsophalangeal joint began to redness and swelling, accompanied by severe pain, acute gouty arthritis attacks should also be considered, and the drug treatment is effective.

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Gouty arthritis at interphalangeal joint of foot after sildenafil use: A case report

Abstract: Sildenafil use may cause gouty arthritis, and surgical decompression may be helpful for definitive diagnosis and symptom relief in atypical presentation of gout.

Cited by 9 publications

References 7 publications

Psoriasis Related Gout Arthritis In The Big Toe Interphalangeal Joint: A Case Report

Psoriasis Related Gout Arthritis In The Big Toe Interphalangeal Joint: A Case Report

Relationship between hyperuricemia with deposition and sexual dysfunction in males and females

Acute gouty arthritis attacks induced by a great toe injury: a case report and literature review

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