Gout – Practicable Interdisciplinary Insights for the Clinician on a Surgeon’s Perspective

Schmidt, Ingo W. Schröder and Bett ina E.

doi:10.15226/2475-4676/3/3/00144

Cited by 2 publications

(2 citation statements)

References 45 publications

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“…These results were consistent with the associations between PRKCZ and STK11 hypomethylation and development of gout ( Table 2 ). Family history of gout is associated with other markers of severity such as polyarticular gout and tophi formation [ 50 , 51 ]. These observations suggest that PRKCZ and STK11 hypomethylation could be associated with more severe gout phenotypes in addition to gout susceptibility.…”

Section: Resultsmentioning

confidence: 99%

“…The results indicated that hypomethylation in PRKCZ and STK11 was associated with familial clustering of gout ( Supplementary Figure 71 ). Familial clustering of gout is associated with polyarticular manifestation and presence of tophi [ 50 , 51 ], both of which are indicative of severe gout. These findings suggest that PRKCZ and STK11 hypomethylation might impact not only disease susceptibility but might also impact family histories and clinical phenotypes in gout patients.…”

Section: Discussionmentioning

confidence: 99%

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Cell lineage-specific methylome and genome alterations in gout

Tseng

Liao

Wong

et al. 2021

Aging

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In this study, we examined data from 69 gout patients and 1,455 non-gout controls using a MethylationEPIC BeadChip assay and Illumina HiSeq platform to identify lineage-specific epigenetic alterations and associated genetic factors that contributed to gouty inflammation. Cell lineage-specific differentially methylated sites were identified using CellDMC after adjusting for sex, age, alcohol drinking, smoking status, and smoking history (total pack-years). Different cell lineages displayed distinct differential methylation. Ingenuity Pathway Analysis and NetworkAnalyst indicated that many differential methylated sites were associated with interleukin-1β expression in monocytes. On the UCSC Genome Browser and WashU Epigenome Browser, metabolic trait, cis-methylation quantitative trait loci, genetic, and functional annotation analyses identified nine methylation loci located in interleukin-1β-regulating genes ( PRKCZ, CIDEC, VDAC1, CPT1A, BIRC2, BRCA1, STK11, and NLRP12 ) that were associated specifically with gouty inflammation. All nine sites mapped to active regulatory elements in monocytes. MoLoTool and ReMap analyses indicated that the nine methylation loci overlapped with binding sites of several transcription factors that regulated interleukin-1β production and gouty inflammation. Decreases in PRKCZ and STK11 methylation were also associated with higher numbers of first-degree relatives who also had gout. The gouty-inflammation specific methylome and genome alterations could potentially aid in the identification of novel therapeutic targets.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Cell lineage-specific methylome and genome alterations in gout

Tseng

Liao

Wong

et al. 2021

Aging

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Clinical-therapeutic and recuperatory features in a patient with pluripatology: ischemic stroke, ischemic heart disease (sechelar myocardial infarction), chronic kidney disease and monstrous gout

Stoica

Chipăruș

Lapadat

et al. 2019

BALNEO

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Introduction: gout is a chronic inflammatory arthropathy produced by depositing crystals of monosodium uric acid (in joints and tissues) following an anomaly (genetics or acquired) in the purine metabolism (1,2). The manifestations of the disease are: hyperuricemia, recurrent episodes of acute arthritis, the presence of tophi, chronic kidney disease, urinary lithiasis(2). Stroke represents„ the rapid development of localized or global clinical signs of cerebral dysfunction with symptoms exceeding 24 hours, leading to death, without any other cause, except for vascular origin”. (3) Materials and Methods: with the permission of the THEBA Ethics Commission ( no.17464/14.06.2019), we will present the clinical case of a 57-year-old patient admitted to the TEHBA Neuromuscular Recovery Clinic presenting a right hemiplegia and mixed aphasia after an ischemic stroke in the territory of the left middle cerebral artery, on the background of complex polypathology (monstrous gout arthropathy, chronic smoking, arterial hypertension, myocardial infarction with coronary artery stenosis, chronic kidney disease). Results: the patient did in our clinic a neuro-muscular recovery treatment, adapted to his needs,which consisted of kinetotherapy and speech therapy and received appropriate medical treatment. The clinical evolution of the patient was slowly favorable, with improvement in language disorders and motor control of paralyzed limbs. Conclusions: the case of this patient has several particularities. This is a patient with a vicious life style, with a severe arthropathy, with severe cardio-vascular sufferers, hospitalized for recovering neuro-muscular deficits after an ischemic stroke. Despite limited prognosis, the patient has improved ADL and the quality of life after recovery treatment. Key words: stroke, hemiplegia, poly-pathologic, ischemic,

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Gout – Practicable Interdisciplinary Insights for the Clinician on a Surgeon’s Perspective

Cited by 2 publications

References 45 publications

Cell lineage-specific methylome and genome alterations in gout

Cell lineage-specific methylome and genome alterations in gout

Clinical-therapeutic and recuperatory features in a patient with pluripatology: ischemic stroke, ischemic heart disease (sechelar myocardial infarction), chronic kidney disease and monstrous gout

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