Gout in Older Adults: The Atherosclerosis Risk in Communities Study

Burke, Bridget Teevan; Köttgen, Anna; Law, Amanda J.; Grams, Morgan E.; Baer, Alan N.; Coresh, Josef; McAdams‐DeMarco, Mara

doi:10.1093/gerona/glv120

Cited by 29 publications

(34 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Ten articles explored hypertension as a risk factor for gout [6-10, 24, 26, 28, 29, 36], of which five articles compared the associations between hypertension and incidence gout in men and women. Three [6,25,29] found increased incidence in both genders, one [8] found the incidence of gout in hypertensive patients to only be raised in men and another found the risk of gout was only increased in female hypertensive patients [28]. Five further articles examined risk in male only samples.…”

Section: Hypertensionmentioning

confidence: 99%

“…Thirteen articles (39.4%) examined the incidence of gout in only one gender (Men = 10, Women = 3), the remaining 20 articles (60.6%) compared both genders. Age as a risk factor was examined in four articles [6][7][8][9], ethnicity in two [10,11], dietary risk factors in 16 articles [6][7][8][9][12][13][14][15][16][17][18][19][20][21][22][23], comorbidities and metabolic disorders in 13 [6][7][8][9][24][25][26][27][28][29][30][31][32] and medication use in seven [6,[26][27][28][33][34][35].…”

Section: Literature Searchmentioning

confidence: 99%

“…The results of the NOS quality appraisal of the included articles can be found in Additional file 1: Table S1. Nineteen (57.6%) of the 33 articles used a specific group of participants in their studies (the Health Professionals Follow-Up Study and the Nurse's Health Study [12,15,16,18,19,22,24,30], student cohorts [10,36], Atherosclerosis Risk in Communities Study (ARIC) [27,28,33], Third Harvard Growth Study cohort [37], healthy, male runners [13] and hotel managers and their associates [20]), which are unlikely to represent the general population. All but one article recruited exposed and non-exposed participants from the same cohort [10].…”

Section: Quality Assessmentmentioning

confidence: 99%

See 2 more Smart Citations

Gender-specific risk factors for gout: a systematic review of cohort studies

et al. 2019

View full text Add to dashboard Cite

Background: Though gout is more prevalent in men than women, it remains unclear whether gender influences risk factors for incident gout. We aimed to systematically review all cohort studies examining risk factors for the development of gout by gender. Methods: MEDLINE, EMBASE, CINAHL and the Cochrane Library were searched from inception to March 2019. Risk factors for gout examined were: age, ethnicity, consumption of alcohol, meat, seafood, dairy products, purine-rich vegetables, coffee and fructose, vitamin C intake, the Dietary Approaches to Stop Hypertension (DASH) diet, metabolic syndrome, BMI, waist and chest circumference, waist-to-hip ratio, weight change, diabetes mellitus, dyslipidaemias, renal disease, psoriasis, hypertension, diuretic use and anti-diabetic medication. Cohort studies were included if examining (at least) one of these risk factors for gout in either gender in the general population or primary care. Sample characteristics from included articles and their reported risk estimates were described using narrative synthesis. Results: Thirty-three articles were included, 20 (60.6%)directly compared risk factors by gender, 10 (30.3%) used men-only samples, 3 (9.1%) used women-only samples. Articles comparing risk across genders found similar increases in most risk factors. However, in men, metabolic syndrome (Hazard Ratio (95% CI) 1.37(1.20-1.58)) presented a risk of incident gout compared to none in women (> 50 years 1.15(0.85-1.54); ≤50 years 1.29(0.76-2.17)). Compared to men, women showed greater associated risk with higher consumption of fish and shellfish (HR (95% CI) Men: 1.02 (0.86-1.22); Women 1.36 (1.12-1.65)). Conclusions: Risk factors for developing gout did not typically differ between genders and therefore similar preventative advice can be provided. Exceptions were metabolic syndrome in men and excessive seafood consumption in women, but these singular articles need further examination and in general more research into the risk factors for gout which includes women is required.

show abstract

Section: Hypertensionmentioning

confidence: 99%

Section: Literature Searchmentioning

confidence: 99%

Section: Quality Assessmentmentioning

confidence: 99%

See 1 more Smart Citation

Gender-specific risk factors for gout: a systematic review of cohort studies

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Gout is a common form of inflammatory arthritis in older adults , with a prevalence of 9.0% for men and 3.3% for women by age 65 years, and 13.3% for men and 6.2% for women by age 75 years . In older adults, there is a greater burden of gout than in younger adults.…”

Section: Introductionmentioning

confidence: 99%

Physical Function, Hyperuricemia, and Gout in Older Adults

Burke

Köttgen

Law

et al. 2015

Arthritis Care & Research

Self Cite

View full text Add to dashboard Cite

Objectives Gout prevalence is high in older adults and those affected are at risk of physical disability, yet it is unclear whether they have worse physical function. Methods We studied gout, hyperuricemia, and physical function in 5,819 older adults (age ≥ 65) attending the 2011–2013 Atherosclerosis Risk in Communities Study visit, a prospective US population-based cohort. Differences in lower extremity [Short Physical Performance Battery (SPPB) and 4 meter walking speed] and upper extremity function (grip strength) by gout status and by hyperuricemia prevalence were estimated in adjusted ordinal logistic regression (SPPB) and linear regression (walking speed and grip strength) models. Lower scores or times signify worse function. The prevalences of poor physical performance (first quartile) by gout and hyperuricemia were estimated using adjusted modified Poisson regression. Results 10% of participants reported a history of gout and 21% had hyperuricemia. There was no difference in grip strength by history of gout (P=0.77). Participants with gout performed worse on the SPPB test; they had 0.77-times (95%CI:0.65,0.90; P=0.001) the prevalence odds of 1-unit increase in SPPB score and were 1.18-times (95%CI:1.07,1.32; P=0.002) more likely to have poor SPPB performance. Participants with a history of gout had slower walking speed (mean difference = −0.03, 95%CI: −0.05, −0.01; P<0.001) and were 1.19-times (95%CI:1.06,1.34; P=0.003) more likely to have poor walking speed. Similarly, SPPB score and walking speed, but not grip strength, were worse in participants with hyperuricemia. Conclusion Older adults with gout and hyperuricemia are more likely to have worse lower but not upper extremity function.

show abstract

“…Gout is a common inflammatory arthritis that is associated with hyperuricemia , and its prevalence and incidence have increased in recent years . There is growing recognition that gout is not a disease affecting just men.…”

mentioning

confidence: 99%

Gout and Risk of Fracture in Women: A Prospective Cohort Study

Paik

Kim

Feskanich

et al. 2017

Arthritis & Rheumatology

View full text Add to dashboard Cite

Objective Uric acid may be linked to bone health through its anti-oxidant or pro-oxidant effects, thereby affecting bone resorption and formation, or through inhibition of vitamin D activation and higher parathyroid hormone level. Prior studies on the relation between uric acid and bone mineral density have demonstrated conflicting results. To date, there are no prospective studies examining the relation between gout, a disease characterized by hyperuricemia and inflammation, and hip or wrist fracture risk in women. Methods We conducted a prospective observational study of gout and risk of incident wrist and hip fracture in women participating in the Nurses’ Health Study (n=103,799 at baseline with 14 years of follow-up for the wrist fracture analysis and 22 years of follow-up for the hip fracture analysis). Gout history and wrist and hip fracture were assessed by biennial questionnaires. Cox proportional-hazards models were used to simultaneously adjust for potential confounders. Results There were 3,769 incident wrist fractures (1990–2004) and 2,147 incident hip fractures (1990–2012), with 107 wrist and 117 hip fractures among participants with gout. The multivariable-adjusted relative risk of wrist fracture in women with a history of gout compared with women without gout was 1.12 (95% CI 0.92 to 1.36). The multivariable-adjusted relative risk of hip fracture in women with a history of gout compared with women without gout was 1.38 (95% CI 1.14 to 1.68). Conclusion A history of gout is associated with a modestly increased risk of hip fracture but not significantly associated with risk of wrist fracture in women.

show abstract

Gout in Older Adults: The Atherosclerosis Risk in Communities Study

Abstract: These findings suggest that traditional and genetic risk factors in middle age may be useful for identifying those at risk of gout in older age.

Cited by 29 publications

References 24 publications

Gender-specific risk factors for gout: a systematic review of cohort studies

Gender-specific risk factors for gout: a systematic review of cohort studies

Physical Function, Hyperuricemia, and Gout in Older Adults

Gout and Risk of Fracture in Women: A Prospective Cohort Study

Contact Info

Product

Resources

About