Gout and risk of non-alcoholic fatty liver disease

Kuo, Chang‐Fu; Yu, Kuang‐Hui; Luo, Shue‐Fen; Chiu, Chien-Hung; Ko, Yousang; Hwang, Jawl‐Shan; Tseng, Wen-Yi; Chang, Hsiao-Chun; Chen, H. W.; See, Lai‐Chu

doi:10.3109/03009741003742797

Cited by 48 publications

(29 citation statements)

References 30 publications

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“…We also show that this accounts for an important mechanism by which fructose induces hepatic fat accumulation. Together, our study may provide a mechanism for why soft drink intake is strongly linked with fatty liver (2,3,53,54) and why uric acid is such a potent predictor of NAFLD (13)(14)(15)(16)(17)(18)(19)(20)(21)(22). Further studies investigating the role of purine-degrading pathways and metabolites in metabolic syndrome seem warranted.…”

Section: Discussionmentioning

confidence: 88%

“…Chronic administration of diets enriched in fructose also raises both fasting and 24-h uric acid levels (10,11), and studies of the general popula-tion have linked soft drink intake with increased serum uric acid levels (12). Given this information, it is not surprising that an elevated serum uric acid has been repeatedly shown to both predict as well as to be common in subjects with NAFLD (13)(14)(15)(16)(17)(18)(19)(20)(21)(22).…”

Section: Nonalcoholic Fatty Liver Disease (Nafld)mentioning

confidence: 99%

“…Serum Uric Acid Levels Positively Correlate with Hepatic Steatosis in Humans Independent of Obesity-As mentioned in the Introduction, NAFLD is strongly associated with hyperuricemia (13)(14)(15)(16)(17)(18)(19)(20)(21)(22), but one potential explanation could be because many patients with hyperuricemia have obesity and metabolic syndrome. One potential way to determine whether hyperuricemia may predict NAFLD independent of obesity is to examine the hemodialysis population, as hyperuricemia is common even when obesity is absent.…”

Section: Uric Acid Mediates Fructose-induced Fat Accumulation Inmentioning

confidence: 99%

See 2 more Smart Citations

Uric Acid Induces Hepatic Steatosis by Generation of Mitochondrial Oxidative Stress

Lanaspa

Sánchez-Lozada

Choi

et al. 2012

Journal of Biological Chemistry

590

547

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Background: Uric acid is an independent risk factor in fructose-induced fatty liver, but whether it is a marker or a cause remains unknown. Results: Hepatocytes exposed to uric acid developed mitochondrial dysfunction and increased de novo lipogenesis, and its blockade prevented fructose-induced lipogenesis. Conclusion: Rather than a consequence, uric acid induces fatty liver Significance: Hyperuricemic people are more prone to develop fructose-induced fatty liver.

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Section: Discussionmentioning

confidence: 88%

Section: Nonalcoholic Fatty Liver Disease (Nafld)mentioning

confidence: 99%

Section: Uric Acid Mediates Fructose-induced Fat Accumulation Inmentioning

confidence: 99%

See 1 more Smart Citation

Uric Acid Induces Hepatic Steatosis by Generation of Mitochondrial Oxidative Stress

Lanaspa

Sánchez-Lozada

Choi

et al. 2012

Journal of Biological Chemistry

590

547

View full text Add to dashboard Cite

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“…There is a graded, positive association between SUA levels and NAFLD severity and elevated SUA levels predict NAFLD risk independently of coexisting MetS features in different ethnicities. [99][100][101][102][103][104][105][106][107][108] Accordingly, a large study found that increased SUA levels were associated with cirrhosis and elevated serum liver enzymes, independent of potential confounders, in 5,518 participants during a mean follow-up of 12.9 years. 96 Further studies are needed to ascertain whether reducing SUA levels would prevent NAFLD/NASH development and progression.…”

Section: Metabolic Syndromementioning

confidence: 99%

Epidemiological modifiers of non-alcoholic fatty liver disease: Focus on high-risk groups

Lonardo

Bellentani

Argo

et al. 2015

Digestive and Liver Disease

400

318

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We aimed to illustrate the epidemiology of nonalcoholic fatty liver disease in high-risk groups, which were identified based on existing literature. To this end, PubMed was searched to retrieve original articles published through May 2015 using relevant and pertinent keywords "nonalcoholic fatty liver disease" and "diabetes", "obesity", "hyperlipidemia", "familial heterozygous hypobelipoproteinemia", "hypertension", "metabolic syndrome", "ethnicity", "family history" or "genetic polymorphisms".We found that age, sex and ethnicity are major physiologic modifiers of the risk of nonalcoholic fatty liver disease, along with belonging to "nonalcoholic fatty liver disease families" and carrying risk alleles for selected genetic polymorphisms. Metabolic syndrome, diabetes, obesity, mixed hyperlipidaemia and hypocholesterolemia due to familial hypobetalipoproteinaemia are the major metabolic modifiers of nonalcoholic fatty liver disease risk. Compared to these metabolic conditions, however, arterial hypertension appears to carry a relatively more modest risk of nonalcoholic fatty liver disease.A better understanding of the epidemiology of nonalcoholic fatty liver disease may result in a more liberal policy of case finding among high-risk groups.

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“…In recent years, an association between elevated serum uric acid concentrations and NAFLD has been reported (2-9). Some authors have concluded that hyperuricemia is an independent risk factor for NAFLD, and is even related to its histologic severity (7).…”

Section: Introductionmentioning

confidence: 99%

Serum uric acid levels and non-alcoholic fatty liver disease in Uyghur and Han ethnic groups in northwestern China

Cui

Zhang

et al. 2013

Arq Bras Endocrinol Metab

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Objective: The aim of this study was to compare serum uric acid values in two ethnically distinct Chinese populations: Uyghur, with a high prevalence of nonalcoholic fatty liver disease, and Han, with a lower prevalence. Subjects and methods: Serum uric acid and several clinical features and laboratory tests relevant to the metabolic syndrome were measured in 4,157 Uyghur and 6,448 Han subjects in a health examination program. The diagnosis of hepatic steatosis was established by abdominal ultrasound examination. Results: The prevalence of nonalcoholic fatty liver disease was 42.3% and 33.3% among Uyghur and Han subjects, respectively. The corresponding prevalence of hyperuricemia was 8.8% and 14.7%. The mean concentration of serum uric acid in Uyghurs also was lower than in Hans (282.75 vs. 310.79 µmol/L; p < 0.01). However, in both populations, the prevalence of nonalcoholic fatty liver disease was increased in association with increasing serum uric acid concentrations, a trend that was more pronounced in Uyghur than in Han subjects (OR 3.279 and 3.230, respectively). Several components of the metabolic syndrome were more pronounced in Uyghurs than in Hans. Conclusions: Serum uric acid is an independent risk factor in nonalcoholic fatty liver disease in both Uyghurs and Hans, but other risk factors may be more important in the differences in prevalence of the disease between the two ethnic groups. Arq Bras Endocrinol Metab. 2013;57(8):617-22 Keywords Non-alcoholic fatty liver disease; serum uric acid; Uyghur; Han; hyperuricemia RESUMO Objetivo: O objetivo deste estudo foi comparar os valores de ácido úrico em duas populações chinesas etnicamente diferentes: Uyghur, com alta prevalência de doença hepática gordurosa não alcoó-lica, e Han, com prevalência mais baixa. Sujeitos e métodos. A concentração sérica de ácido úrico e várias características clínicas e testes laboratoriais relevantes para a síndrome metabólica foram determinados em 4.157 indivíduos Uyghur e 6.448 indivíduos Han submetidos a um programa de checkups. O diagnóstico de esteatose hepática foi estabelecido por ultrassom abdominal. Resultados: A prevalência de doença hepática gordurosa não alcoólica foi de 42,3% e 33,3% entre os indivíduos Uyghur e Han, respectivamente. A prevalência correspondente de hiperuricemia foi de 8,8% e 14,7%. A concentração sérica média de ácido úrico em Uyghurs também foi mais baixa do que em Hans (282,75 contra 310,79 µmol/L; p < 0,01). Entretanto, em ambas as populações, a prevalência de doença hepática gordurosa não alcoólica aumentou com a elevação da concentração sérica de ácido úrico, uma tendência mais pronunciada em Uyghurs do que em Hans (OR 3,279 e 3,230, respectivamente). Vários componentes da síndrome metabólica são mais pronunciados em Uyghurs do que em Hans. Conclusões: A concentração sérica de ácido úrico é um fator de risco independente para a doença hepática gordurosa não alcoólica tanto em Uyghurs quando em Hans, mas outros fatores de risco podem ser mais importantes nas diferenças na prevalên...

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Gout and risk of non-alcoholic fatty liver disease

Abstract: There was an independent association between gout and the risk for NAFLD. In addition, there was a dose-response relationship between SU and NAFLD in subjects with and without gout.

Cited by 48 publications

References 30 publications

Uric Acid Induces Hepatic Steatosis by Generation of Mitochondrial Oxidative Stress

Uric Acid Induces Hepatic Steatosis by Generation of Mitochondrial Oxidative Stress

Epidemiological modifiers of non-alcoholic fatty liver disease: Focus on high-risk groups

Serum uric acid levels and non-alcoholic fatty liver disease in Uyghur and Han ethnic groups in northwestern China

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