Gout and risk for subsequent coronary heart disease. The Meharry-Hopkins Study

Gelber, Allan C.; Klag, Michael J.; Mead, Lucy A.; Thomas, John M.; Thomas, D J; Pearson, Thomas A.; Hochberg, Marc C.

doi:10.1001/archinte.157.13.1436

Cited by 46 publications

(53 citation statements)

References 17 publications

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“…8 However, on the other hand, many studies argue that the observed association between uric acid and atherosclerosis is attributable to an indirect association of hyperuricemia with cardiovascular risk factors 9 or clustering of these metabolic and hemodynamic risk factors, designated "metabolic syndrome." 10,11 Although many studies have focused on the presence or absence of an independent relationship between uric acid and coronary and cerebrovascular artery diseases, [12][13][14] thus far, few have examined the independence of the relationship between serum uric acid and carotid atherosclerosis. 15,16 To this end, the current study had 2 goals: first, to investigate the association between uric acid levels and metabolic syndrome in individuals undergoing general health screening; and second, to assess whether there was an independent association of uric acid with the prevalence of carotid plaque in individuals with or without metabolic syndrome after adjusting for other confounding risk factors for atherosclerosis.…”

mentioning

confidence: 99%

Association Between Serum Uric Acid, Metabolic Syndrome, and Carotid Atherosclerosis in Japanese Individuals

Ishizaka

Toda

et al. 2005

ATVB

262

197

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Objective-There are few data available on possible independent association between uric acid and carotid atherosclerosis.Here we first sought to investigate association between uric acid levels and metabolic syndrome in Japanese; second, we assessed whether there is an independent association of uric acid with prevalence of carotid atherosclerosis in individuals subdivided according to gender and metabolic syndrome status. Methods and Results-Cross-sectional data from 8144 individuals who underwent general health screening were analyzed.After adjusting for age, total cholesterol, and smoking status, the odds ratios (95% CI) of sex-specific quartiles of serum uric acid for metabolic syndrome were 1.0, 1.06 (0.60 to 1.87), 2.18 (1.30 to 3.64), and 4.17 (2.56 to 6.79) in women, and 1.0, 0.92 (0.74 to 1.14), 1.52 (1.25 to 1.65), and 1.97 (1.61 to 2.40) in men. After adjusting for age, serum levels, total cholesterol, and smoking status, prevalence of carotid plaque was higher in subjects in the second, third, and fourth quartiles of uric acid level with odds ratios (95% CI) of 1.24 (1.01 to 1.52), 1.37 (1.11 to 1.68), and 1.31 (1.05 to 1.63), respectively, in men without metabolic syndrome but not in men with metabolic syndrome or in women with or without metabolic syndrome. Conclusion-The prevalence of metabolic syndrome showed a graded increase according to serum uric acid values in both genders. In men who did not have metabolic syndrome, uric acid was found to be an independent risk factor for incidence of carotid plaque.

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mentioning

confidence: 99%

Association Between Serum Uric Acid, Metabolic Syndrome, and Carotid Atherosclerosis in Japanese Individuals

Ishizaka

Toda

et al. 2005

ATVB

262

197

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“…The self report of gout by this physician cohort had excellent concordance with the American College of Rheumatology Criteria for gout [ 14 ]. Gelber et al [ 10 ] adjusted for confounders of cholesterol, smoking, body mass index, alcohol use, hypertension, and diabetes. It was not clear if age was adjusted for in the model.…”

Section: Introductionmentioning

confidence: 64%

“…Three prospective observational cohort studies met the search criteria: 1) Framingham Heart study [ 9 ]; 2) the Meharry-Hopkins study [ 10 ]; 3) The Multiple Risk Factor Intervention Trial (MRFIT) [ 11•• ]; and the Health Professionals Follow-up study [ 12•• ]. The signifi cant heterogeneity among the studies in terms of data collection strategies, case defi nition, and outcome defi nition precluded a formal statistical meta-analysis.…”

Section: Introductionmentioning

confidence: 99%

“…Data from the Meharry and Johns Hopkins Precursors cohorts of male physicians formed the basis for the study of gout and CVD risk by Gelber et al [ 10 ]. The MeharryHopkins study was assembled from the Johns Hopkins medical student classes of 1948 through 1964 ( n = 1337) and eight classes of Meharry doctors (1958)(1959)(1960)(1961)(1962)(1963)(1964)(1965).…”

Section: Introductionmentioning

confidence: 99%

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Gout and coronary artery disease: Epidemiologic clues

Krishnan

2008

Curr Rheumatol Rep

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Gout is the leading cause of inflammatory arthritis, typically affecting men and characterized by intermittent, abrupt onset of intense inflammation. The association between gout, atherosclerosis, and vascular disease has been noted in medical literature since the end of the 19th century, yet it has not been well studied. This review critically appraises the few epidemiologic studies that ask if gout is a risk factor for coronary artery disease. An exhaustive literature search using search engines and cross-referencing found four major studies and several smaller studies that have evaluated gout as a risk factor for coronary artery disease. The available studies were too heterogeneous to permit formal meta-analysis. Although there are gaps in evidence pointing to a causative pathway, overall, evidence exists for a relationship between gouty arthritis and coronary artery disease independent of traditional risk factors.

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“…Past US and multinational epidemiologic studies have supported [9,19•,52-55] and refuted [56][57][58] an association of elevated serum urate with cardiovascular disease. Furthermore, associations may be seen in only particular patient subgroups, such as for women [53,59] and those with particular body physiques [41].…”

Section: Cardiovascular Diseasementioning

confidence: 99%

Recent advances in the epidemiology of gout

Mikuls

2005

Curr Rheumatol Rep

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Gout remains among the most common of all inflammatory arthridities with an incidence that appears to have risen. Evidence is accumulating to support lifestyle and dietary factors, such as heavy consumption of beer and liquor as well as diets rich in meats and seafood as important gout risk factors. There is also a renewed interest in important associations between gout and other comorbidities like hypertension and cardiovascular disease. The importance of hyperuricemia on health considerations beyond the musculoskeletal system is an area worthy of even more study.

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Gout and risk for subsequent coronary heart disease. The Meharry-Hopkins Study

Abstract: These results, in black and white male physicians, do not suggest a role in men for targeting gout identification in the primary prevention of CHD.

Cited by 46 publications

References 17 publications

Association Between Serum Uric Acid, Metabolic Syndrome, and Carotid Atherosclerosis in Japanese Individuals

Association Between Serum Uric Acid, Metabolic Syndrome, and Carotid Atherosclerosis in Japanese Individuals

Gout and coronary artery disease: Epidemiologic clues

Recent advances in the epidemiology of gout

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