Gout and its relation to lipid metabolism. II. Correlations between uric acid, lipid, and lipoprotein levels in gout.

Mielants, Herman; Em, Veys; Weerdt, A de

doi:10.1136/ard.32.6.506

Cited by 7 publications

(5 citation statements)

References 4 publications

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“…Gout was reported to be associated with hypercholesterolaemia (Becker, 1960), but Gibson & Graharne (1974) could not confirm this association. In the present study with normal subjects, no correlation was observed between the increasing serum uric acid level and cholesterol, in agreement with observations on gouty patients (Mielants et al 1973b). Similarly there was no correlation between levels of phospholipids and uric acid in the present study.…”

Section: Discussionsupporting

confidence: 92%

“…It is concluded that prolonged fasting and refeeding leads to increases of both serum uric acid and triglycerides. The association between hypertriglyceridaemia and hyperuricaemia is unlikely to be through a common enzyme (Mielants et al 1973b), but rather through feedback interaction between the pathways of metabolism mediated through smallmolecular-weight effectors or similar modulators.…”

Section: Discussionmentioning

confidence: 99%

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The effects of fasting in Ramadan

et al. 1978

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I . The changes in serum levels of uric acid and lipids during I month of starvation-refeeding were 2. Uric acid levels increased linearly with the duration of the experiment. The increase was positively 3. Triglycerides increased at a faster rate than uric acid implying that the increase in uric acid was secon-4. It was concluded that the purine and lipid synthetic pathways are linked through a common smallmeasured in sixteen male volunteers. correlated with the increase in serum triglycerides but not with cholesterol or phospholipids. dary to that of the lipid. molecular-weight effector rather than through the sharing of a common enzyme.Throughout the holy lunar month of Ramadan, moslems are expected to abstain from food and drink daily between dawn and sunset. The incidence of renal colic or of angina pectoris increases noticeably during this Islamic month especially when the latter coincides with the hot, dry summer in the Sudan. The question whether these complaints are due to increases of risk factors predisposing to renal calculi and to coronary vascular disease consequent upon the dietary pattern during Ramadan remained to be answered.When breaking their fast at sunset, Sudanese moslems consume large volumes of sugarsweetened juices to quench thirst, and foods rich in carbohydrates are eaten from sunset till dawn. Nicholls & Scott (1972) reported that energy restriction leads to a decrease in the plasma level of uric acid and attributed this partly to the relative hydration state associated with weight loss. Increased carbohydrate intake, especially sucrose, is known to increase the triglyceride concentration in serum (Anderson, Grande, Matsumoto & Keys, I 963 ; Nestel, Carrol & Haverstein, 1970; Fry, Spector, Connor & Connor, 1973; Roberts, 1973; Sacks, Castelli, Donner & Kass, 19-75),The present study reports the changes in the serum levels of uric acid and lipids during daily starvation-refeeding over a period of 28 d in an attempt to test their relationship to the associated complaints of renal colic or angina. Correlation studies were used to test the relation between uric acid and lipid metabolism during periods of maximal dehydration and rehydration throughout the 28 d. M A T E R I A L S A N D M E T H O D SThe present investigation took place in the Facuty of Medicine, University of Khartoum, Sudan. Sixteen male students aged between 20 and 22 years volunteered for the study, which was to span the one month of Ramadan. All volunteers were healthy as evident from a general medical examination and none was receiving any medication.Venous blood was collected into clean tubes and allowed to clot at room temperature.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

The effects of fasting in Ramadan

et al. 1978

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“…These treatments also suppressed macrophage-specific mROS production ( Figure 8, D and E). Given that flares of acute joint inflammation correlate with elevated serum FA levels (11,12), we examined the effects of elevated serum FAs on MSU crystal-driven, macrophage-specific mROS production through acute intravenous administration of intralipid (32). Coinjection of intralipid with the fluorescent FA analog BODIPY FL C 16 , which permits live imaging of FA transport within zebrafish larvae (33), into the circulation of Tg(kdrl:RFP) (34) larvae (possessing red fluorescent vasculature) revealed the immediate transport of injected lipids throughout the vasculature and progressive accumulation in the hindbrain ventricle within 1 hour ( Figure 9, A and B).…”

Section: Resultsmentioning

confidence: 99%

“…Previous studies have revealed that FAs can promote the proinflammatory phenotype of macrophages, in part through activation of NF-κB signaling (41). Furthermore, flares of acute joint inflammation in individuals with gout correlate with elevated serum FA levels (11,12), and the release of FAs into the circulation is a common metabolic consequence of a number of risk factors predisposing patients to flares (e.g., excessive alcohol and food consumption) (42). Of note, stearic acid has been shown to directly augment MSU crystal-stimulated IL-1β production by human PBMCs and murine macrophages through a TLR2/caspase 1-dependent mechanism (13).…”

Section: Discussionmentioning

confidence: 99%

“…One of these factors is fatty acids (FAs), which are a metabolic consequence of excessive alcohol and food consumption (risk factors for gout flares). Flares of acute joint inflammation in patients with gout correlate with elevated serum FA levels (11,12). In addition, FAs have been shown to augment MSU crystal-stimulated IL-1β secretion from human peripheral blood mononuclear cells (PBMCs) and murine macrophages (13).…”

Section: Introductionmentioning

confidence: 99%

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Blocking fatty acid–fueled mROS production within macrophages alleviates acute gouty inflammation

Hall¹,

Sanderson²,

Lawrence³

et al. 2018

Journal of Clinical Investigation

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Gout is the most common inflammatory arthritis affecting men. Acute gouty inflammation is triggered by monosodium urate (MSU) crystal deposition in and around joints that activates macrophages into a proinflammatory state, resulting in neutrophil recruitment. A complete understanding of how MSU crystals activate macrophages in vivo has been difficult because of limitations of live imaging this process in traditional animal models. By live imaging the macrophage and neutrophil response to MSU crystals within an intact host (larval zebrafish), we reveal that macrophage activation requires mitochondrial ROS (mROS) generated through fatty acid oxidation. This mitochondrial source of ROS contributes to NF-κB-driven production of IL-1β and TNF-α, which promote neutrophil recruitment. We demonstrate the therapeutic utility of this discovery by showing that this mechanism is conserved in human macrophages and, via pharmacologic blockade, that it contributes to neutrophil recruitment in a mouse model of acute gouty inflammation. To our knowledge, this study is the first to uncover an immunometabolic mechanism of macrophage activation that operates during acute gouty inflammation. Targeting this pathway holds promise in the management of gout and, potentially, other macrophage-driven diseases.

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Klinische Wertigkeit der Hyperuricämie. Beziehung zu anderen Krankheiten

Wolfram¹

1976

Gicht

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Gout and its relation to lipid metabolism. II. Correlations between uric acid, lipid, and lipoprotein levels in gout.

Cited by 7 publications

References 4 publications

The effects of fasting in Ramadan

The effects of fasting in Ramadan

Blocking fatty acid–fueled mROS production within macrophages alleviates acute gouty inflammation

Klinische Wertigkeit der Hyperuricämie. Beziehung zu anderen Krankheiten

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