Gout: an Asia‐Pacific update

Abstract

Even though, Hippocrates recognized gout as an affection of older men and a product of high living long back in 5th century BC, this painful condition promises to accompany humanity to the 21st century. The incidence is progressively rising and females are also affected in the modern era. There are also regional and ethnic variations in the incidence, the genetics of which is being studied. The recommended best therapy for the acute attacks and long term prophylaxis has improved remarkably in the recent years. However, patients are often treated inadequately and risk factors for their disease are not well explored in daily practice. Although well designed long term studies of current and newer treatment are welcomed, educating doctors especially the primary care physicians who manage majority of gout cases, in optimizing the currently available management options would improve the present care.Key words: disease aetiology and pathogenesis -human, gout, metabolic and crystal arthropathies drug treatment, metabolic and crystal arthropathies epidemiology, metabolic and crystal arthropathies inflammasome.

Epidemiology and Prevalence of Gout in Mainland China: an Updated Systematic Review and Meta-Analysis

“…Some possible reasons included dietary changes, environmental factors, obesity, and diabetes, which are associated with increased risk of gout [80]. Our reported rate was lower than those in developing countries such as Indonesia (7.0%) [85]. There are several possible factors that contribute to the heterogeneity in the above prevalence rates.…”

An uncommon case of gouty arthritis in a teenage boy

“…Gouty arthritis, both acute and chronic, is a clinical diagnosis of joint inflammation due to the deposition of monosodium urate (MSU) crystals. [1][2][3] Other than joints, MSU crystals can also deposit in soft tissues such as cartilage and renal parenchyma, manifesting as tophaceous gout and uric acid nephrolithiasis. 1,3 Hyperuricemia at serum uric acid (SUA) level around 420 µmol/L is an important predisposing factor for MSU crystals deposition causing the clinical syndromes.…”

“…[1][2][3] Other than joints, MSU crystals can also deposit in soft tissues such as cartilage and renal parenchyma, manifesting as tophaceous gout and uric acid nephrolithiasis. 1,3 Hyperuricemia at serum uric acid (SUA) level around 420 µmol/L is an important predisposing factor for MSU crystals deposition causing the clinical syndromes. 1,2 Risk factors associated with gout can be divided into nonmodifiable and modifiable.…”

“…1,3 Hyperuricemia at serum uric acid (SUA) level around 420 µmol/L is an important predisposing factor for MSU crystals deposition causing the clinical syndromes. 1,2 Risk factors associated with gout can be divided into nonmodifiable and modifiable. Male gender, advancing age, ethnicities, and genetic inheritance are risk factors from the former, while high purine diet, alcohol ingestion, obesity, and medications use are from the latter.…”

“…Male gender, advancing age, ethnicities, and genetic inheritance are risk factors from the former, while high purine diet, alcohol ingestion, obesity, and medications use are from the latter. [1][2][3] The prevalence of gout in the United States (US) has been increasing since the year 1970, with an estimated three to eight million citizens diagnosed, which is more than 3% of the US adults. 3 This increasing trend was also observed worldwide possibly due to unhealthy eating habits, sedentary lifestyle, and presence of concurrent comorbidities such as diabetes, chronic kidney disease, and cardiovascular diseases.…”