Under conditions of increasing of industrial consumption of sugar in Russia and applying specific requirements for sugar as primary commodity, issues of flexibility and readjustment of process lines for production of sugar of prescribed properties become relevant. Maintaining the quality and safety of products in this case can be ensured by the transition of the process control system to a new paradigm, including the improvement of tools in the form of measurement methods. As a basis for the methodology of forming the system of control methods, three principles have been proposed: the package principle, the acquisition of standard and extended case methods, and the unification of methods presentation. The package principle as a tool of the rule-making methodology, with its detailed elaboration in standardization, has been considered in detail. It is shown that in order to ensure the compatibility of operational control methods, it makes sense to provide unified approaches to their development, essential content, construction and presentation, which is possible by adopting the package principle used in standardization. The necessity of expanding the nomenclature of control parameters of the technological flow of sugar production was considered in detail; the existing prerequisites were shown. It was proposed to provide the implementation of nomenclature variations of control parameters on the basis of the formation of two case methods, differentiated according to the destination of the sugar produced - for population or industrial consumers. It is noted that control parameters of the technological flow of sugar production are the quantities related to the subject of quantitative chemical analysis, the practical side of which is reflected by analytical methods. Due to the current variety of attributes of methods presentation, their harmonization is required both by means of the unification of the presentation of measurement methods of the same parameters for different control objects according to their substantive essence, and by means of the unification of the text presentation of the methodology. The principles considered together constitute the essence of the methodological approach to the formation of the system of control methods of the technological sugar production flow.