Goshuyuto, a Traditional Japanese Medicine for Migraine, Inhibits Platelet Aggregation in Guinea-Pig Whole Blood

Hibino, Tomoko; Yuzurihara, Mitsutoshi; Terawaki, Kiyoshi; Kanno, Hitomi; Kase, Yoshio; Takeda, Atsüshi

doi:10.1254/jphs.08058fp

Cited by 27 publications

(19 citation statements)

References 15 publications

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“…It is prescribed, according to traditional Chinese medical practice, for the treatment of headache, abdominal pain, dysentery, amenorrhea, and postpartum hemorrhage (1). Our previous study demonstrated that goshuyuto, a traditional Japanese medicine, had an antiaggregatory effect of platelets in guinea pigs and that Evodiae Fructus was the active substance in the components of goshuyuto (2). Also, we demonstrated that goshuyuto constricted isolated rat thoracic aorta and that the constrictive effects was due to Evodiae Fructus (3).…”

Section: Introductionmentioning

confidence: 92%

Synephrine, a Component of Evodiae Fructus, Constricts Isolated Rat Aorta via Adrenergic and Serotonergic Receptors

et al. 2009

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Abstract. We investigated the effects of Evodiae Fructus and synephrine, one of the components of Evodiae Fructus, on blood vessels. We found that Evodiae Fructus (1 × 10 −6 -3 × 10 −4 g/mL) had constrictive effects on rat aorta. The vasoconstrictive effects of Evodiae Fructus were significantly inhibited by pretreatment with prazosin (adrenergic α 1 -receptor antagonist), BRL15572 [5-hydroxytryptamine (5-HT) 1D antagonist], and ketanserin (5-HT 2A antagonist), but its vasoconstrictive effects were not inhibited by pretreatment with SB216641 (5-HT 1B antagonist) or propranolol (adrenergic β-receptor antagonist). These results suggest that Evodiae Fructus constricts rat aorta via adrenergic and serotonergic receptors. We also investigated the constrictive effects of synephrine on blood vessels. The vasoconstrictive effects of synephrine (1 × 10 −7 -3 × 10 −5 mol /L) were significantly inhibited by pretreatment with prazosin, BRL15572, and ketanserin. However, its constrictive effects were not inhibited by pretreatment with SB216641 and propranolol. The pA 2 values of prazosin or ketanserin were nearly equal between Evodiae Fructus and synephrine. Because the constrictive effects of both Evodiae Fructus and synephrine were exerted via adrenergic α 1 -receptors and serotonergic (5-HT 1D and 5-HT 2A ) receptors, synephrine may be one of the important components in the constrictive effects of Evodiae Fructus.

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Section: Introductionmentioning

confidence: 92%

Synephrine, a Component of Evodiae Fructus, Constricts Isolated Rat Aorta via Adrenergic and Serotonergic Receptors

et al. 2009

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“…Its two herbal components, zingiberis and evodiae, have been shown to inhibit collagen-induced platelet aggregation. Interestingly, 6-gingerol and 6-shogaol as two constituents of zingiberis can inhibit platelet aggregation by inhibition of cyclooxygenase-1 activity (Hibino et al, 2008). In another study, anti-migraine properties of Sapindustrifoliatus water extract has been linked to both inhibition of 5-HT 2B receptor and release of platelet serotonin (Arulmozhi et al, 2004).…”

Section: Effects On Platelet Activitymentioning

confidence: 97%

Migraine: Molecular Basis and Herbal Medicine

Ansari¹,

Rafiee²,

Emamgholipour³

et al. 2012

Advanced Topics in Neurological Disorders

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“…5) In addition, we elucidated that goshuyuto inhibited the platelet aggregation of guinea pigs. 6) These results suggest that goshuyuto affects the vascular system, but there have not been any reports of pharmacological evaluation of the vascular response to goshuyuto. In the present study, we investigated the effects of goshuyuto on vascular response and its mechanism in the isolated rat aorta.…”

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confidence: 88%

Goshuyuto, a Traditional Japanese Medicine, and Aqueous Extracts of Evodiae Fructus Constrict Isolated Rat Aorta via Adrenergic and/or Serotonergic Receptors

Hibino

Yuzurihara

Kanno

et al. 2009

Biological & Pharmaceutical Bulletin

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Effects of goshuyuto, a traditional Japanese medicine, on vascular constriction were examined using isolated strips of rat aorta. Goshuyuto (1؋10 ؊5 to 1؋10 ؊3 g/ml) caused constriction of aorta strips in a dose-dependent manner. The vasoconstrictive effects of goshuyuto were significantly inhibited by pretreatment with prazosin, an adrenergic a a 1 receptor antagonist. The constrictive effects were partially inhibited by pretreatment with BRL15572, a 5-HT 1D antagonist, and ketanserin, a 5-HT 2A antagonist. However, the constrictive effects were not inhibited by pretreatment with SB216641, a 5-HT 1B antagonist, or propranolol, an adrenergic b b receptor antagonist. In addition, aqueous extracts of Evodiae Fructus, one of the constituent medicinal herbs of goshuyuto, caused constriction of aorta strips strongly, but aqueous extracts of Zizyphi Fructus, Ginseng Radix, and Zingiberis Rhizoma, the other constituents of goshuyuto, did not have much effect on the vascular response of rat aorta strips. Also, synephrine, which is one of the ingredients of Evodiae Fructus, constricted the rat aorta. These results suggest that goshuyuto constricts rat aorta strips and that the mechanisms involve the adrenergic and/or serotonergic receptors. Also, it may be suggested that Evodiae Fructus and synephrine play the important role in the vasoconstrictive effects of goshuyuto on rat aorta strips.

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Goshuyuto, a Traditional Japanese Medicine for Migraine, Inhibits Platelet Aggregation in Guinea-Pig Whole Blood

Cited by 27 publications

References 15 publications

Synephrine, a Component of Evodiae Fructus, Constricts Isolated Rat Aorta via Adrenergic and Serotonergic Receptors

Synephrine, a Component of Evodiae Fructus, Constricts Isolated Rat Aorta via Adrenergic and Serotonergic Receptors

Migraine: Molecular Basis and Herbal Medicine

Goshuyuto, a Traditional Japanese Medicine, and Aqueous Extracts of Evodiae Fructus Constrict Isolated Rat Aorta via Adrenergic and/or Serotonergic Receptors

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