Goserelin (Zoladex) and the anaemic patient

Vercellini, Paolo; Crosignani, Pier Giorgio

doi:10.1111/j.1471-0528.1994.tb13684.x

Cited by 8 publications

(1 citation statement)

References 18 publications

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“…The significantly higher post‐operative haemoglobin and haematocrit levels recorded by us in the triptorelin compared with the immediate surgery group are related to the higher pre‐operative values induced by three months of amenorrhoea. The normalisation of haematologic indexes in anaemic subjects constitutes another advantage of pre‐operative GnRH agonist administration 15,17,18,27,28 , although similar results might be obtained with simple iron supplementation to patients while on the waiting list 29 . No transfusion was needed in the present study.…”

Section: Discussionsupporting

confidence: 69%

Treatment with a gonadotrophin releasing hormone agonist before hysterectomy for leiomyomas: results of a multicentre, randomised controlled trial

Davies

1998

BJOG

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Objectives To ascertain whether uterine shrinkage induced by a gonadotrophin releasing hormone Design A multicentre, prospective, randomised, controlled study.Participants One hundred and twenty-seven premenopausal women with a uterine volume of 12 to 16 gestational weeks.Interventions Twelve weeks of triptorelin depot treatment before hysterectomy or immediate surgery.Main outcome measures Number of vaginal and abdominal hysterectomies, operating time, blood loss, degree of difficulty of the procedure, perioperative serum haemoglobin and haematocrit levels, hospital stay, and patients' overall satisfaction with treatment.Results After randomisation, four women withdrew from the study, leaving 60 women in the triptorelin arm and 63 in the immediate surgery arm. At baseline evaluation a vaginal hysterectomy was indicated in seven women allocated to pre-operative medical therapy (1 2%), and in 10 of those allocated to immediate surgery (l6Y0). Clinical assessment after the 12-week GnRH agonist course showed that abdominal hysterectomy was no longer indicated in 25/53 women (470/0) as a vaginal procedure appeared appropriate. Thus the overall rate of indication for a vaginal procedure in the pre-operative medical treatment arm was 32/60 cases (53%), with a between-group difference of 37% (95% CI, 26% to 51%; x21 = 19.18, P c 0.0001; OR 6.06; 95Y0 CI, 2.60 to 14.10). Pre-and post-operative serum haemoglobin and haematocrit levels were significantly higher in the GnRH agonist than in the immediate surgery arm. No appreciable difference was observed between the groups in the other intra-and post-operative variables, including patients' satisfaction.Conclusions Pre-operative GnRH agonist therapy increased the rate of vaginal hysterectomy in selected women with fibroids and uterine volume of 12 to 16 gestational weeks.agonist before hysterectomy for fibroids increases the possibility of a vaginal procedure.

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Section: Discussionsupporting

confidence: 69%