Gorlin Syndrome: Sequential Digital Dermoscopy of Palpebral Basal Cell Carcinomas in a Patient Treated With Vismodegib

Mena-Vergara, Luis; Silva-Astorga, Mariana; Carrasco-Cancino, Carolina; Muñoz-Uslar, Leoncio

doi:10.5826/dpc.1201a19

Cited by 2 publications

(1 citation statement)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Dermoscopy is a non-invasive, easily accessible, and rapid tool used in dermatology not only for diagnostic processes but also for monitoring therapeutic responses [2][3][4][5] in the pediatric population [6,7]. To ensure correct use, reproducibility, and comparability of dermoscopic terms, in 2015, Kittler et al published the standardized terminology as a result of the third consensus conference of the International Society of Dermoscopy.…”

Section: Introductionmentioning

confidence: 99%

Dermoscopic Patterns of Genodermatoses: A Comprehensive Analysis

Plázár,

Meznerics,

Pálla

et al. 2023

Biomedicines

View full text Add to dashboard Cite

(1) Background: Genodermatoses are a clinically and genetically heterogenous group of inherited skin disorders. Diagnosing inherited skin diseases is a challenging task due to their rarity and diversity. Dermoscopy is a non-invasive, easily accessible, and rapid tool used in dermatology not only for diagnostic processes but also for monitoring therapeutic responses. Standardized terminologies have been published for its proper use, reproducibility, and comparability of dermoscopic terms. (2) Methods: Here, we aimed to investigate dermoscopic features in various genodermatoses by conducting a systematic review and comparing its results to our own findings, data of patients diagnosed with genodermatoses at the Department of Dermatology, Venereology and Dermatooncology, Semmelweis University. (3) Results: Our systematic search provided a total of 471 articles, of which 83 reported both descriptive and metaphoric dermoscopic terminologies of 14 genodermatoses. The literature data were then compared to the data of 119 patients with 14 genodermatoses diagnosed in our department. (4) Conclusion: Dermoscopy is a valuable tool in the diagnosis of genodermatoses, especially when symptoms are mild. To enable the use of dermoscopy as an auxiliary diagnostic method, existing standardized terminologies should be extended to more genodermatoses.

show abstract

Section: Introductionmentioning

confidence: 99%

Dermoscopic Patterns of Genodermatoses: A Comprehensive Analysis

Plázár,

Meznerics,

Pálla

et al. 2023

Biomedicines

View full text Add to dashboard Cite

show abstract

Vismodegib in Gorlin‐Goltz syndrome: A systematic review

Palmeiro,

Carvalho,

Gonçalves Castro

et al. 2024

Aust J Dermatology

View full text Add to dashboard Cite

Treatment with Hedgehog Inhibitors in Gorlin‐Goltz syndrome (GGS) yields favourable objective clinical responses, yet secondary resistance and class‐related toxicity restrict treatment duration. This study aims to review current data on GGS patients undergoing vismodegib therapy, focusing on treatment duration, clinical outcomes and schedule modifications. A systematic search of the PubMed database was conducted for English articles from 1993 to 2023, identifying 31 papers suitable for inclusion. A total of 351 patients, with a mean age of 52 years, were analysed. The average treatment duration was 9.3 months for patients who discontinued treatment, and 25.1 months for those who continued vismodegib at the time this study was published. Vismodegib achieved a complete response rate of 44%. Treatment interruption predominantly occurred due to side effects (69.1%) and secondary resistance (9.1%). The use of alternative regimens, although not compromising efficacy, may enhance treatment compliance. Further investigations are warranted to ascertain the optimal treatment regimen and timeline for GGS patients. Schedule modifications offer promise in ameliorating side effects and facilitating long‐term treatment.

show abstract

Gorlin Syndrome: Sequential Digital Dermoscopy of Palpebral Basal Cell Carcinomas in a Patient Treated With Vismodegib

Cited by 2 publications

References 2 publications

Dermoscopic Patterns of Genodermatoses: A Comprehensive Analysis

Dermoscopic Patterns of Genodermatoses: A Comprehensive Analysis

Vismodegib in Gorlin‐Goltz syndrome: A systematic review

Contact Info

Product

Resources

About