Gorham's disease—vanishing bone of the cervical spine

Demir, Mustafa Kemal; Yapıcıer, Özlem; Toktaş, Zafer Orkun; Yılmaz, Baran; Akakın, Akın; Konya, Deniz

doi:10.1016/j.spinee.2015.08.045

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Other Symptoms and Visceral Involvement1

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2022

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“…These findings are often associated with other lymphatic diffuse anomalies such as chylothorax (since the establishment mechanism is the same), lymphatic flow into the pericardial area or involvement of thoracic duct. However, these are rare findings in GSD (less than 10 cases reported in the literature), but they can be life-threatening (56, 71,72,73,74,75,76,77,78).…”

Section: Other Symptoms and Visceral Involvementmentioning

confidence: 99%

Current concepts from diagnosis to management in Gorham–Stout disease: a systematic narrative review of about 350 cases

et al. 2022

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Patients with Gorham–Stout disease (GSD) present progressive destruction and resorption of bone. Typical bone-related symptoms include swelling, pain and functional impairment in the region involved. The three aspects of GSD etiopathology are osteoclasts, angiogenesis/lymphangiogenesis and osteoblast function. Multi-targeted pharmacological approach includes innovative options and represent milestones of treatment, sometimes associated with radiotherapy. Surgery is mainly used to treat complications: pathologic/impending fractures, spinal instability or deformities and chylothorax. In this narrative review, we highlight current standards in diagnosis, clinical management and therapeutic strategies.

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