Gordon Murray and the artificial kidney in Canada

McKellar, Shelley

doi:10.1093/ndt/14.11.2766

Cited by 7 publications

(4 citation statements)

References 5 publications

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“…Dr Gordon Murray, a surgeon in Toronto unaware of Kolff's work, built a machine with which he did a hemodialysis in December 1946. Although it was successful, his machine never came to anything for reasons given in an excellent 1999 article entitled, “Gordon Murray and the artificial kidney in Canada.” This extra ordinary man was named a companion of the Order of Canada in 1967. Dr Kolff was inducted into the Inventors’ Hall of Fame in 1985, and in 1990 was named by Life magazine in its list of the 100 Most Important Americans of the 20th Century.…”

Section: First Successful Hemodialysis With Kolff's Machinementioning

confidence: 99%

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RussellPalmer:Forgotten champion

Rae

2011

Hemodialysis International

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Section: First Successful Hemodialysis With Kolff's Machinementioning

confidence: 99%

“…Although it was successful, his machine never came to anything for reasons given in an excellent 1999 article entitled, "Gordon Murray and the artificial kidney in Canada." 8…”

Section: First Successful Hemodialysis With Kolff's Machinementioning

confidence: 99%

RussellPalmer:Forgotten champion

Rae

2011

Hemodialysis International

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“…Indeed, even after the technical problems began to be resolved with the availability of heparin and cellophane, the pioneering works of Willem Kolff (1911–2009), Nils Alwall (1904–1986), and Gordon Murray (1884–1976) in the 1940s remained experimental for another two decades, not achieving clinical application until the mid‐1950s (13). By then, Gordon Murray had abandoned his work on dialysis altogether (29).…”

Section: Abel’s Contributionsmentioning

confidence: 99%

The History of Dialysis: The Wonderful Apparatus of John Jacob Abel Called the “Artificial Kidney”

Eknoyan

2009

Seminars in Dialysis

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Hemodialysis, which now provides life-saving therapy to millions of individuals, began as an exploratory attempt to sustain the lives of selected patients in the 1950s. That was a century after the formulation of the concept and determination of the laws governing dialysis. The first step in the translation of the laboratory principles of dialysis to living animals was the "vividiffusion" apparatus developed by John Jacob Abel (1859-1938), dubbed the "artificial kidney" in the August 11, 1913 issue of The Times of London reporting the demonstration of vividiffusion by Abel at University College. The detailed article in the January 18, 1914 of the New York Times, reproduced here, is based on the subsequent medical reports published by Abel et al. Tentative attempts of human dialysis in the decade that followed based on the vividiffusion apparatus of Abel and his materials (collodion, hirudin, and glass) met with failure and had to be abandoned. Practical dialysis became possible in the 1940s and thereafter after cellophane, heparin, and teflon became available. Abel worked in an age of great progress and experimental work in the basic sciences that laid the foundations of science-driven medicine. It was a "Heroic Age of Medicine," when medical discoveries and communicating them to the public were assuming increasing importance. This article provides the cultural, social, scientific, and medical background in which Abel worked, developed and reported his wonderful apparatus called the "artificial kidney."

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“…Among the critically ill patients renal replacement t therapy was reported among 5 to 6% of patients and is associated with in hospital mortality rate of 50 to 80% 1,2,3 Acute kidney injury (AKI), requiring renal replacement therapy (RRT) occurs in 5 to 6% of seriously ill patients and is related with high mortality and significant health resource utilization 4,5,6 and an important cause of increased mortality is in the intensive care unit (ICU) patients worldwide. 7 The optimum time for initiation, method and dosing of renal -replacement therapy remains uncertain more from more than 60 years after first use of hemodialysis is patients with acute kidney injury. 5,6 Different studied suggested that more intensive doses of RRT shows better outcomes in patients with acute kidney injury.…”

Section: Introductionmentioning

confidence: 99%

Comparing prescribed and delivered doses in ICU patients on continuous renal replacement therapy at King Fahad Hospital Saudi Arabia.

Manzoor¹,

Bhatt²,

Singh

et al. 2020

TPMJ

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The outcomes of several studies to assess the dose of dialysis during renal replacement therapy (RRT) created confusion among the clinicians to considered that dose of dialysis can influence the outcomes of patients with acute kidney injury (AKI). Suitable dose of CRRT is associated with improved survival in critically ill patients with acute kidney injury (AKI). Among different studies Effluent Volume per weight and unit time (mL/kg/h) used to express prescribed effluent rates, in our study same unit used express the effluent rates. Purpose of this study is to find the difference among dosage of CRRT based on effluent rate prescription and actual delivered effluent rate by monitoring records of dialysis. Study Design: Prospective observational cohort study. Setting: King Fahad Hospital Medina Saudi Arabia. Period: 1st June 2016 to 31st December 2016. Material & Methods: Two hundred acute kidney injury patients admitted in ICU on CRRT at rate of 20ml/kg using pre-filter continuous venovenous hemodia-filtration (CVVHDF), among (AKI) patients prescribed doses were compared with the actual dose with in the duration of 24 hours to find out difference between prescribed and actual dose. Results: Findings of our study shows that. Mean average dose of dialysis delivered per day was only 16 hours which is 21% of prescription of pre-dilution CVVHDF. Patients were receiving 14ml/Kg of continues renal replacement therapy (CRRT) with the lack of 21% dilution correction factor. The average number of hours/day on continuous renal replacement therapy was 14.1±2.41, with a mean flow rate of 1.36±0.31 L/h (averaged over 24 h). The delivered doses were significantly lowered then the prescribed doses with (P < 0.001). 30% of doses was missing during CRRT among patients with acute kidney diseases admitted in ICU at king Fahad hospital Saudi Arabia (P-value <0.001). Conclusions: We concluded that during dialysis patients did not received the prescribed dose in comparison to actual delivered dose which effects the survival of critical ill patients with acute kidney injury.

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Gordon Murray and the artificial kidney in Canada

Cited by 7 publications

References 5 publications

RussellPalmer:Forgotten champion

RussellPalmer:Forgotten champion

The History of Dialysis: The Wonderful Apparatus of John Jacob Abel Called the “Artificial Kidney”

Comparing prescribed and delivered doses in ICU patients on continuous renal replacement therapy at King Fahad Hospital Saudi Arabia.

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