Goose, Duck and Garganey

Munekata, Paulo E. S.; Tomašević, Igor; Franco, Daniel; Barba, Francisco J.; Gómez, Belén; Lorenzo, José M.

doi:10.1007/978-3-030-05484-7_11

Cited by 1 publication

(1 citation statement)

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“…First, over 50% of duck meat products consumed in the world are solely dependent on the large and intensive duck breeding in China (Fig. 1) (Adzitey and Adzitey, 2011; Munekata et al ., 2019). Second, as a growth‐promoting agent, tetracycline has long been used in feeding additives for poultry breeding (e.g., ducks; Ministry of Agriculture and Rural Affairs, P. R. China, 2019).…”

Section: Discussionmentioning

confidence: 99%

The poultry pathogen Riemerella anatipestifer appears as a reservoir for Tet(X) tigecycline resistance

Umar

Chen

Tang

et al. 2021

Environmental Microbiology

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The transferability of bacterial resistance to tigecycline, the 'last-resort' antibiotic, is an emerging challenge of global health concern. The plasmidborne tet(X) that encodes a flavin-dependent monooxygenase represents a new mechanism for tigecycline resistance. Natural source for an ongoing family of Tet(X) resistance determinants is poorly understood. Here, we report the discovery of 26 new variants [tet(X18) to tet(X44)] from the poultry pathogen Riemerella anatipestifer, which expands extensively the current Tet(X) family. R. anatipestifer appears as a natural reservoir for tet(X), of which the chromosome harbours varied copies of tet(X) progenitors. Despite that an inactive ancestor rarely occurs, the action and mechanism of Tet(X2/4)-P, a putative Tet(X) progenitor, was comprehensively characterized, giving an intermediate level of tigecycline resistance. The potential pattern of Tet(X) dissemination from ducks to other animals and humans was raised, in the viewpoint of ecological niches. Therefore, this finding defines a large pool of natural sources for Tet(X) tigecycline resistance, heightening the need of efficient approaches to manage the inter-species transmission of tet(X) resistance determinants.

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Section: Discussionmentioning

confidence: 99%