Goodpasture's Syndrome Superimposed on Membranous Nephropathy. A Case Report

Thitiarchakul, Supachai; Lal, Sunder M.; Luger, Alan M.; Ross, Gilbert

doi:10.1177/039139889501801203

Cited by 17 publications

(19 citation statements)

References 6 publications

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“…5,13,19 In approximately two thirds of the two dozen or so published reports, there was evidence of evolution from preexisting nephrotic syndrome, and in about half, a previous kidney biopsy showed typical MN. Progression to end-stage renal disease (ESRD) has usually been rapid, but the diagnosis has rarely been made at an early enough stage to expect intensive treatment to be successful.…”

Section: Membranous Nephropathymentioning

confidence: 99%

Antiglomerular Basement Membrane Disease and Goodpasture's Disease

Phelps¹,

Turner²

2010

Comprehensive Clinical Nephrology

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Section: Membranous Nephropathymentioning

confidence: 99%

Antiglomerular Basement Membrane Disease and Goodpasture's Disease

Phelps¹,

Turner²

2010

Comprehensive Clinical Nephrology

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“…Anti-GBM GN preceding MN, though rare, has been described in adults [1][2][3], and a single case in a 17-year-old smoker has been reported [4]. To the best of our knowledge, this is the second and youngest reported case in a child.…”

Section: Discussionmentioning

confidence: 90%

Evolution of antiglomerular basement membrane glomerulonephritis into membranous glomerulonephritis

et al. 2007

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Antiglomerular basement membrane glomerulonephritis (anti-GBM GN) is a rare disease characterized by autoantibodies to the alpha 3 chain of type IV collagen in the GBM. It is also known as Goodpasture's syndrome when associated with pulmonary hemorrhage due to autoantibodies to the alpha 3 chain of type IV collagen also present in pulmonary alveoli. Even more rare is the evolution of anti-GBM GN into membranous nephropathy (MN). We report the management of a 9-year-old Caucasian girl with anti-GBM GN that evolved into MN and briefly review the literature.

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“…The likely pathological mechanism underlying the course of immune complex-glomerulonephritis with exposure of GBM antigens might subsequently lead to the production of anti-GBM antibodies, as supported by animal model studies [16]. Moreover, several case reports describe membranous nephropathy evolved to anti-GBM disease [17,18]. On the other hand, progression of anti-GBM disease to membranous nephropathy has been documented in several reports [19][20][21].…”

Section: Discussionmentioning

confidence: 95%

Anti-Glomerular Basement Membrane Disease Accompanied by Membrano Proliferative Glomerulonephritis: A Case Report

Hm¹

2017

J Kidney

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Anti-glomerular basement membrane disease is characterized by autoimmunity to antigenic sites on type IV collagen of the glomerular basement membrane. The majority of patients present with rapidly progressive glomerulonephritis and alveolar hemorrhage. The occurrence of anti-glomerular basement membrane disease and other types of glomerulonephritis, such as membranous nephropathy, IgA nephropathy and antineutrophil cytoplasmic antibodies associated vasculitis, is not uncommon. Herein, we describe a patient who presented with worsening kidney function, hemoptysis, and detectable circulating anti-glomerular basement membrane disease antibodies in serum. A kidney biopsy revealed the classical pathological finding of anti-glomerular basement membrane disease, with linear deposition of IgG along the glomerular basement membrane and diffuses extracapillary crescentic sclerosing glomerulonephritis. Likewise, the biopsy revealed a membranoproliferative pattern with abundant C3 deposition. Subsequently, the patient was diagnosed with anti-glomerular basement membrane disease and the rare concurrent existence of membranoproliferative glomerulonephritis. The patient's clinical course was unusual for the anti-glomerular basement membrane disease, with slower progressive decline in renal function and nephrotic range proteinuria. Unfortunately, the presence of membranoproliferative glomerulonephritis did not change the prognosis and the patient lost his renal function irretrievably despite immunosuppressive treatment.

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Goodpasture's Syndrome Superimposed on Membranous Nephropathy. A Case Report

Cited by 17 publications

References 6 publications

Antiglomerular Basement Membrane Disease and Goodpasture's Disease

Antiglomerular Basement Membrane Disease and Goodpasture's Disease

Evolution of antiglomerular basement membrane glomerulonephritis into membranous glomerulonephritis

Anti-Glomerular Basement Membrane Disease Accompanied by Membrano Proliferative Glomerulonephritis: A Case Report

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