Good's Syndrome and Pernicious Anemia.

Abstract

In a rare case of Good's syndrome with pernicious anemia, one year after thymectomy, recurrent respiratory infections developed. Both panhypoglobulinemia and pernicious anemia were disclosed. An immunological analysis revealed the absence of circulating B cells, but T cell numbers and mitogenic responses were normal. Regular gammaglobulin and vitamin B12 injections were successful in keeping the patient symptomfree.

Myelodysplasia followed by Good's Syndrome: A unique manifestation associated with thymoma

“…Due to the dysfunction of both B and T lymphocytes, patients with Good's syndrome are more vulnerable to various pathogens, such as encapsulated bacteria, virus, fungus, and opportunistic infections. In addition to myasthenia gravis and Good's syndrome, paraneoplastic syndromes associated with thymoma (parathymic syndromes) could also present with autoimmune‐mediated hematological disorders, such as pure red cell aplasia, aplastic anemia, agranulocytosis, hemolytic anemia, pernicious anemia, and paroxysmal nocturnal hemoglobinuria [1–6]. Furthermore, myelodysplastic syndrome (MDS) is a heterogeneous group of clonal hematopoietic stem cell diseases characterized by cytopenia(s), dysplasia in one or more lineages, and ineffective hematopoiesis, and is associated with a variable risk of transformation to acute leukemia.…”