Good Neighbors: The Niche that Fine Tunes Mammalian Intestinal Regeneration

Palikuqi, Brisa; Rispal, Jérémie; Klein, Ophir D.

doi:10.1101/cshperspect.a040865

Cited by 14 publications

(10 citation statements)

References 92 publications

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“…ISCs, which are marked by Lgr5, and their transit amplifying descendants self-renew and differentiate along the various intestinal epithelial lineages (Barker et al, 2007;Gehart and Clevers, 2019). Maintenance of ISCs is dependent on the niche, which is comprised of several cell types and is an essential source of Wnt ligands and modulators (McCarthy et al, 2020a;Palikuqi et al, 2021). Among these molecules, R-spondins (RSPOs), which bind to LGR receptors (LGR4 and LGR5 in the intestine), potentiate Wnt signaling (de Lau et al, 2011;Glinka et al, 2011) by stabilizing Frizzled receptors (Hao et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Lymphangiocrine signals are required for proper intestinal repair after cytotoxic injury

Palikuqi¹,

Rispal²,

Reyes³

et al. 2022

Cell Stem Cell

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Section: Introductionmentioning

confidence: 99%

Lymphangiocrine signals are required for proper intestinal repair after cytotoxic injury

Palikuqi¹,

Rispal²,

Reyes³

et al. 2022

Cell Stem Cell

Self Cite

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“…This secretion pattern results in higher BMP signaling activity in the villi and lower BMP signaling in the crypts of the small intestine. Similarly, however, cells in the mesenchyme responding to BMP stimulation should also be in a state of BMP signaling activation due to the abundance of BMP ligands in the mesenchyme[ 115 ]. In juvenile intestinal polyps, BMP signaling inactivation means that all cells no longer respond to BMP signaling, and malignant proliferative intestinal polyps appear[ 116 ].…”

Section: Uc Intestinal Inflammatory Response Processmentioning

confidence: 99%

Molecular regulation mechanism of intestinal stem cells in mucosal injury and repair in ulcerative colitis

Zheng¹,

Duan²

2023

World J Gastroenterol

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Ulcerative colitis (UC) is a chronic nonspecific inflammatory disease with complex causes. The main pathological changes were intestinal mucosal injury. Leucine-rich repeat-containing G protein coupled receptor 5 (LGR5)-labeled small intestine stem cells (ISCs) were located at the bottom of the small intestine recess and inlaid among Paneth cells. LGR5+ small ISCs are active proliferative adult stem cells, and their self-renewal, proliferation and differentiation disorders are closely related to the occurrence of intestinal inflammatory diseases. The Notch signaling pathway and Wnt/β-catenin signaling pathway are important regulators of LGR5-positive ISCs and together maintain the function of LGR5-positive ISCs. More importantly, the surviving stem cells after intestinal mucosal injury accelerate division, restore the number of stem cells, multiply and differentiate into mature intestinal epithelial cells, and repair the damaged intestinal mucosa. Therefore, in-depth study of multiple pathways and transplantation of LGR5-positive ISCs may become a new target for the treatment of UC.

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“…Thus, tight control of BMP activation is essential, with low BMP signaling in crypts and higher BMP signaling toward the more differentiated cells in villus [36]. BMP signaling prevents epithelial dedifferentiation, and pathway attenuation through stromal Gremlin1 upregulation was required for adaptive reprogramming in intestinal regeneration [37].…”

Section: Isc Niche and Cell Fate Differentiationmentioning

confidence: 99%

Gut microbiota‐stem cell niche crosstalk: A new territory for maintaining intestinal homeostasis

Chen

Johnston

et al. 2022

iMeta

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Intestinal epithelium undergoes rapid cellular turnover, relying on the local niche, to support intestinal stem cells (ISCs) function and self‐renewal. Research into the association between ISCs and disease continues to expand at a rapid rate. However, the detailed interaction of ISCs and gut microbes remains to be elucidated. Thus, this review witnessed major advances in the crosstalk between ISCs and gut microbes, delivering key insights into (1) construction of ISC niche and molecular mechanism of how to jointly govern epithelial homeostasis and protect against intestinal diseases with the participation of Wnt, bone morphogenetic protein, and Notch; (2) differentiation fate of ISCs affect the gut microbiota. Meanwhile, the presence of intestinal microbes also regulates ISC function; (3) microbiota regulation on ISCs by Wnt and Notch signals through pattern recognition receptors; (4) how do specific microbiota‐related postbiotics influence ISCs to maintain intestinal epithelial regeneration and homeostasis that provide insights into a promising alternative therapeutic method for intestinal diseases. Considering the detailed interaction is still unclear, it is necessary to further explore the regulatory role of gut microbiota on ISCs to utilize microbes to alleviate gut disorders. Furthermore, these major advances collectively drive us ever closer to breakthroughs in regenerative medicine and cancer treatment by microbial transplantation in the clinic.

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Good Neighbors: The Niche that Fine Tunes Mammalian Intestinal Regeneration

Cited by 14 publications

References 92 publications

Lymphangiocrine signals are required for proper intestinal repair after cytotoxic injury

Lymphangiocrine signals are required for proper intestinal repair after cytotoxic injury

Molecular regulation mechanism of intestinal stem cells in mucosal injury and repair in ulcerative colitis

Gut microbiota‐stem cell niche crosstalk: A new territory for maintaining intestinal homeostasis

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