Good interrater reliability of a new grading system in detecting traumatic bone marrow lesions in the knee by dual energy CT virtual non-calcium images

Cao, Jin; Wang, Yimin; Kong, Xiangquan; Cheng, Yang; Wang, Peng

doi:10.1016/j.ejrad.2015.03.003

Cited by 46 publications

(32 citation statements)

References 29 publications

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“…18 Cao et al subsequently confirmed these results on 32 patients and reported sensitivities and specificities ranging from 74 to 91% and 99 to 100%, respectively, depending on the femoral or tibial location of the BMLs. 19 Ai et al showed that these BMLs can be detected using DECT up to 10 weeks after trauma, confirming previous data from MRI. 20 In the ankle, Guggenberger et al reported that sensitivity and specificity of DECT was $ 90% and 91%, respectively.…”

Section: Understanding Of Disease Pathophysiologysupporting

confidence: 64%

Dual-Energy CT: Basic Principles, Technical Approaches, and Applications in Musculoskeletal Imaging (Part 2)

Omoumi¹,

Verdun

Guggenberger

et al. 2015

Semin Musculoskelet Radiol

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In recent years, technological advances have allowed manufacturers to implement dual-energy computed tomography (DECT) on clinical scanners. With its unique ability to differentiate basis materials by their atomic number, DECT has opened new perspectives in imaging. DECT has been successfully used in musculoskeletal imaging with applications ranging from detection, characterization, and quantification of crystal and iron deposits, to simulation of noncalcium (improving the visualization of bone marrow lesions) or noniodine images. Furthermore, the data acquired with DECT can be postprocessed to generate monoenergetic images of varying kiloelectron volts, providing new methods for image contrast optimization as well as metal artifact reduction. The first part of this article reviews the basic principles and technical aspects of DECT including radiation dose considerations. The second part focuses on applications of DECT to musculoskeletal imaging including gout and other crystal-induced arthropathies, virtual noncalcium images for the study of bone marrow lesions, the study of collagenous structures, applications in computed tomography arthrography, as well as the detection of hemosiderin and metal particles.

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Section: Understanding Of Disease Pathophysiologysupporting

confidence: 64%

Dual-Energy CT: Basic Principles, Technical Approaches, and Applications in Musculoskeletal Imaging (Part 2)

Omoumi¹,

Verdun

Guggenberger

et al. 2015

Semin Musculoskelet Radiol

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“…The use of a threematerial decomposition model allows for calculation of VNCa images by removing calcium from CT data. To date, few studies have reported the use of the dual-energy VNCa technique to visualize bone marrow in extremities (18,24,32) and in the spine (1,13,31,33).…”

Section: Discussionmentioning

confidence: 99%

“…Advances in dual-energy CT have enabled the direct visualization of bone marrow abnormalities through creation of virtual noncalcium (VNCa) images (18,(24)(25)(26)(27)(28)(29)(30). Previous investigators have used this method to image the extremities and the spine (1,13,18,24,(31)(32)(33)(34). However, prior generations of dual-energy scanners have limited spectral resolution, and therefore, provide limited bone marrow information, especially in complex body regions (eg, spine, pelvis).…”

Section: Study Populationmentioning

confidence: 99%

Vertebral Compression Fractures: Third-Generation Dual-Energy CT for Detection of Bone Marrow Edema at Visual and Quantitative Analyses

et al. 2017

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Purpose To assess the diagnostic performance of a third-generation dual-energy computed tomographic (CT) virtual noncalcium (VNCa) technique for detection of traumatic bone marrow edema in patients with vertebral compression fractures. Materials and Methods This prospective study was approved by the institutional review board. Informed consent was obtained from all participants. Twenty-two consecutive patients with 37 morphologic vertebral fractures were studied between October 2015 and May 2016. All patients underwent dual-energy CT (90 kV and 150 kV with a tin filter) and 3-T magnetic resonance (MR) imaging. Two independent readers visually evaluated all vertebral bodies (n = 163) for the presence of abnormal bone marrow attenuation on VNCa images by using color-coded maps and performed a quantitative analysis of CT numbers on VNCa images. MR images served as the reference standard. CT numbers were subjected to receiver operating characteristic analysis to calculate cutoff values. Results In the visual analysis, VNCa images had an overall sensitivity of 64.0%, specificity of 99.3%, accuracy of 93.9%, positive predictive value of 94.1%, and negative predictive value of 93.8%. The interobserver agreement was excellent (κ = 0.85). CT numbers obtained from VNCa images were significantly different in vertebral bodies with and without edema (P < .001). Receiver operating characteristic analysis revealed an area under the curve of 0.922. A cutoff value of -47 provided sensitivity of 92.0%, specificity of 82.6%, accuracy of 84.0%, positive predictive value of 48.9%, and negative predictive value of 98.3% for the differentiation of edematous vertebral bodies. Conclusion Visual and quantitative analyses of dual-energy VNCa images showed excellent diagnostic performance for assessing traumatic bone marrow edema in vertebral compression fractures. RSNA, 2017 Online supplemental material is available for this article.

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“…The authors found in their small clinical study cohort Fig. 4): A ROI [7] was drawn within the tumor mass in order to obtain a spectral attenuation curve. (b) Axial slice of the DECT staging examination of the same patient: A second ROI [5] was drawn within a left hilar enlarged lymph node in order obtain a spectral attenuation curve.…”

Section: Dect and Subsolid Lung Nodulesmentioning

confidence: 99%

“…Dual energy computed tomography (DECT) has proven its clinical usefulness for tissue characterization over the past years, e.g., in the characterization of bone lesions, renal masses, urinary calculi or coronary plaque components [1][2][3][4][5][6][7][8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Dual-energy snap-shot perfusion CT in suspect pulmonary nodules and masses and for lung cancer staging

Sudarski

Hagelstein

Weis

et al. 2015

European Journal of Radiology

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Good interrater reliability of a new grading system in detecting traumatic bone marrow lesions in the knee by dual energy CT virtual non-calcium images

Cited by 46 publications

References 29 publications

Dual-Energy CT: Basic Principles, Technical Approaches, and Applications in Musculoskeletal Imaging (Part 2)

Dual-Energy CT: Basic Principles, Technical Approaches, and Applications in Musculoskeletal Imaging (Part 2)

Vertebral Compression Fractures: Third-Generation Dual-Energy CT for Detection of Bone Marrow Edema at Visual and Quantitative Analyses

Dual-energy snap-shot perfusion CT in suspect pulmonary nodules and masses and for lung cancer staging

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