“…Furthermore, the pharmacological mechanisms of the bisdioxopiperazine dexrazoxane are not completely understood [7,11]. Several authors have suggested that due to the building of chelates as a metal ion chelator it may, firstly, prevent the formation of free radicals and, secondly, inhibit reversibly topomerase II, therefore working as a protective agent [1,3,7,8,10,11]. The recommended 3-day treatment schedule consists of a daily dose of 1,000 mg/m 2 on the 1st and 2nd days and 500 mg/m 2 on the 3rd day given once [1,2,4,5].…”